首页|The effect of transposable elements on phenotypic variation: insights from plants to humans

The effect of transposable elements on phenotypic variation: insights from plants to humans

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Transposable elements (TEs), originally discovered in maize as controlling elements, are the main components of most eukaryotic genomes.TEs have been regarded as deleterious genomic parasites due to their ability to undergo massive amplification.However, TEs can regulate gene expression and alter phenotypes.Also, emerging findings demonstrate that TEs can establish and rewire gene regulatory networks by genetic and epigenetic mechanisms.In this review, we summarize the key roles of TEs in fine-tuning the regulation of gene expression leading to phenotypic plasticity in plants and humans, and the implications for adaption and natural selection.

transposable elementsgene expressionphenotypic variation

Liya Wei、Xiaofeng Cao

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State Key Laboratory of Plant Genomics and National Plant Gene Research Center (Beijing), CAS Center for Excellence in Molecular Plant Sciences, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

Collaborative Innovation Center of Genetics and Development, Fudan University, Shanghai 200433, China

This work was supported by the National Natural Science Foundation of ChinaThis work was supported by the National Natural Science Foundation of ChinaNational Basic Research Program of Chinaand the State Key Laboratory of Plant GenomicsLiya Wei was supported by the China Postdoctoral Science Foundation

31210103901311230072013CB8352002015B0129-012015M570170

2016

10.1007/s11427-015-4993-2

中国科学:生命科学(英文版)
中国科学院

中国科学:生命科学(英文版)

CSCDSCI
影响因子：0.806
ISSN：1674-7305
年,卷(期)：2016.59(1)
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