The crosstalk between enteric nervous system and immune system in intestinal development,homeostasis and diseases

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外文摘要：The gut is the largest digestive and absorptive organ,which is essential for induction of mucosal and systemic immune responses,and maintenance of metabolic-immune homeostasis.The intestinal components contain the epithelium,stromal cells,immune cells,and enteric nervous system(ENS),as well as the outers,such as gut microbiota,metabolites,and nutrients.The dyshomeostasis of intestinal micro-environment induces abnormal intestinal development and functions,even colon diseases including dysplasia,inflammation and tumor.Several recent studies have identified that ENS plays a crucial role in maintaining the immune homeostasis of gastrointestinal(GI)mi-croenvironment.The crosstalk between ENS and immune cells,mainly macrophages,T cells,and innate lymphoid cells(ILCs),has been found to exert important regulatory roles in intestinal tissue programming,homeostasis,function,and inflammation.In this review,we mainly summarize the critical roles of the interactions between ENS and immune cells in intestinal homeostasis during intestinal devel-opment and diseases progression,to provide theoretical bases and ideas for the exploration of immunotherapy for gastrointestinal diseases with the ENS as potential novel targets.

外文关键词：

enteric nervous systemmacrophagesT cellsinnate lymphoid cellsneuro-immune interactions

作者：

Xindi Wang、Chenbo Ding、Hua-Bing Li

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作者单位：

Shanghai Institute of Immunology,State Key Laboratory of Oncogenes and Related Genes,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaChongqing International Institute for ImmunologyMinistry of Science and Technology of ChinaShanghai Science and Technology CommissionShanghai Science and Technology CommissionShanghai Science and Technology CommissionShanghai Municipal Health CommissionShanghai Municipal Health CommissionChina Postdoctoral Science Foundation

项目编号：

8203004232070917821115402 77822020172021YJC012021 YFA110080020JC141740020140900550020JC14101002022JC0012022XD0472021M702160

出版年：

2024

DOI：

10.1007/s11427-023-2376-0

中国科学:生命科学(英文版)

中国科学院

中国科学:生命科学(英文版)

CSTPCD

影响因子：0.806

ISSN：1674-7305

年,卷(期)：2024.67(1)

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