首页|Effect of autologous bone marrow stem cells-scaffold trans-plantation on the ongoing pregnancy rate in intrauterine adhesion women:a randomized,controlled trial

Effect of autologous bone marrow stem cells-scaffold trans-plantation on the ongoing pregnancy rate in intrauterine adhesion women:a randomized,controlled trial

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Intrauterine adhesion is a major cause of female reproductive disorders.Although we and others uncontrolled pilot studies showed that treatment with autologous bone marrow stem cells made a few patients with severe intrauterine adhesion obtain live birth,no large sample randomized controlled studies on this therapeutic strategy in such patients have been reported so far.To verify if the therapy of autologous bone marrow stem cells-scaffold is superior to traditional treatment in moderate to severe intrauterine adhesion patients in increasing their ongoing pregnancy rate,we conducted this randomized controlled clinical trial.Totally 195 participants with moderate to severe in-trauterine adhesion were screened and 152 of them were randomly assigned in a 1:1 ratio to either group with autologous bone marrow stem cells-scaffold plus Foley balloon catheter or group with only Foley balloon catheter(control group)from February 2016 to January 2020.The per-protocol analysis included 140 participants:72 in bone marrow stem cells-scaffold group and 68 in control group.The ongoing pregnancy occurred in 45/72(62.5％)participants in the bone marrow stem cells-scaffold group which was significantly higher than that in the control group(28/68,41.2％)(RR=1.52,95％CI 1.08-2.12,P=0.012).The situation was similar in live birth rate(bone marrow stem cells-scaffold group 56.9％(41/72)vs.control group 38.2％(26/68),RR=1.49,95％CI 1.04-2.14,P=0.027).Compared with control group,participants in bone marrow stem cells-scaffold group showed more menstrual blood volume in the 3rd and 6th cycles and maximal endometrial thickness in the 6th cycle after hysteroscopic adhesiolysis.The incidence of mild placenta accrete was increased in bone marrow stem cells-scaffold group and no severe adverse elfects were observed.In conclusion,transplantation of bone marrow stem cells-scaffold into uterine cavities of the participants with moderate to severe intrauterine adhesion increased their ongoing pregnancy and live birth rates,and this therapy was relatively safe.

intrauterine adhesionAsherman's syndromeuterine infertilityautologous bone marrow stem cells transplantationendometrial regenerationongoing pregnancy rate

Hui Zhu、Taishun Li、Peizhen Xu、Lijun Ding、Xianghong Zhu、Bin Wang、Xiaoqiu Tang、Juan Li、Pengfeng Zhu、Huiyan Wang、Chenyan Dai、Haixiang Sun、Jianwu Dai、Yali Hu

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Department of Obstetrics and Gynecology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China

Department of Biostatistics,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China

Department of Gynecology,Changzhou Maternal and Child Health Care Hospital,Changzhou Medical Center,Nanjing Medical University,Changzhou 213004,China

Clinical Center for Stem Cell Research,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China

Department of Hematology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China

Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100190,China

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Strategic Priority Research Program of the Chinese Academy of SciencesStrategic Priority Research Program of the Chinese Academy of SciencesNational Natural Science Foundation of ChinaJiangsu Provincial Key Medical CenterJiangsu Provincial Obstetrics and Gynecology Innovation Center

XDA16040302XDA0103050581971336YXZXB2016004CXZX202229

2024

10.1007/s11427-023-2403-7

中国科学:生命科学(英文版)
中国科学院

中国科学:生命科学(英文版)

CSTPCD
影响因子：0.806
ISSN：1674-7305
年,卷(期)：2024.67(1)
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