首页|An effective pharmacological hydrogel induces optic nerve repair and improves visual function

An effective pharmacological hydrogel induces optic nerve repair and improves visual function

扫码查看
原文链接
  • 万方数据
  • 维普
Irreversible eye lesions,such as glaucoma and traumatic optic neuropathy,can cause blindness;however,no effective treatments exist.The optic nerve,in particular,lacks the capacity to spontaneously regenerate,requiring the development of an effective approach for optic nerve repair,which has proven challenging.Here,we demonstrate that a combination of the small molecules 3BDO and trichostatin A(TSA)—which regulate mTOR and HDAC,respectively-packaged in thermosensitive hydrogel for 4-week-sustained release after intravitreal in-jection,effectively induced optic nerve regeneration in a mouse model of optic nerve crush injury.Moreover,this combination of 3BDO and TSA also protected axon projections and improved visual responses in an old mouse model(11 months old)of glaucoma.Taken together,our data provide a new,local small molecule-based treatment for the effective induction of optic nerve repair,which may represent a foundation for the development of pharmacological methods to treat irreversible eye diseases.

retinal ganglion cellaxon regenerationold-age glaucomasmall moleculespharmacological hydrogelvisual function repair

Lipeng Wang、Shan Zhang、Yawen Han、Shuo Tang、Jiarui Li、Lina Bu、Dongyu Zhao、Hongkui Deng

展开 >

Department of Cell Biology,School of Basic Medical Sciences,Peking University Stem Cell Research Center,State Key Laboratory of Natural and Biomimetic Drugs,Peking University Health Science Center,Beijing 100191,China

MOE Key Laboratory of Cell Proliferation and Differentiation,College of Life Sciences,Peking-Tsinghua Center for Life Sciences,Peking University,Beijing 100871,China

Academy for Advanced Interdisciplinary Studies,Peking University,Beijing 100871,China

Department of Ophthalmology,Peking University People's Hospital Eye Diseases and Optometry Institute,Beijing 100871,China

Department of Biomedical Informatics,School of Basic Medical Sciences,Peking University,Beijing 100191,China

Changping Laboratory,Beijing 102206,China

展开 >

国家自然科学基金

32288102

2024

10.1007/s11427-023-2394-3

中国科学:生命科学(英文版)
中国科学院

中国科学:生命科学(英文版)

CSTPCD
影响因子：0.806
ISSN：1674-7305
年,卷(期)：2024.67(3)
  • 56