B cell development and antibody responses in human immune system mice:current status and future perspective

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外文摘要：Humanized immune system(HIS)mice have been developed and used as a small surrogate model to study human immune function under normal or disease conditions.Although variations are found between models,most HIS mice show robust human T cell responses.However,there has been unsuccessful in constructing HIS mice that produce high-affinity human antibodies,primarily due to defects in terminal B cell differentiation,antibody affinity maturation,and development of primary follicles and germinal centers.In this review,we elaborate on the current knowledge about and previous attempts to improve human B cell development in HIS mice,and propose a potential strategy for constructing HIS mice with improved humoral immunity by transplantation of human follicular dendritic cells(FDCs)to facilitate the development of secondary follicles.

外文关键词：

humanized immune system mousehumoral immunitygerminal centerB cellfollicular dendritic cell

作者：

Tao Zhang、Wentao Liu、Yong-Guang Yang

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作者单位：

Key Laboratory of Organ Regeneration & Transplantation of the Ministry of Education,The First Hospital of Jilin University,Changchun 130061,China

National-Local Joint Engineering Laboratory of Animal Models for Human Diseases,Jilin University,Changchun 130061,China

Intemational Center of Future Science,Jilin University,Changchun 130061,China

基金：

国家重点研发计划国家自然科学基金吉林省自然科学基金Department of Human Resource and Social Security of Jilin ProvinceScience Development of Jilin Province,ChinaBethune Medical Department of Jilin University

项目编号：

2021YFA11007008194100820200201191JC2022DJ0220230505029ZP2022JBGS01

出版年：

2024

DOI：

10.1007/s11427-023-2462-8

中国科学:生命科学(英文版)

中国科学院

中国科学:生命科学(英文版)

CSTPCD

影响因子：0.806

ISSN：1674-7305

年,卷(期)：2024.67(4)

参考文献量112