首页|The burgeoning importance of PIWI-interacting RNAs in cancer progression

The burgeoning importance of PIWI-interacting RNAs in cancer progression

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PIWI-interacting RNAs(piRNAs)are a class of small noncoding RNA molecules that specifically bind to piwi protein family members to exert regulatory functions in germ cells.Recent studies have found that piRNAs,as tissue-specific molecules,both play oncogenic and tumor suppressive roles in cancer progression,including cancer cell proliferation,metastasis,chemoresistance and stemness.Additionally,the atypical manifestation of piRNAs and PIWI proteins in various malignancies presents a promising strategy for the identification of novel biomarkers and therapeutic targets in the diagnosis and management of tumors.Nonetheless,the precise functions of piRNAs in cancer progression and their underlying mechanisms have yet to be fully comprehended.This review aims to examine current research on the biogenesis and functions of piRNA and its burgeoning importance in cancer progression,thereby offering novel perspectives on the potential utilization of piRNAs and piwi proteins in the management and treatment of advanced cancer.

PIWI-interacting RNAs/piRNAscancer progressionmetastasischemoresistancestemness

Xinpei Deng、Tianle Liao、Jindong Xie、Da Kang、Yiwei He、Yuying Sun、Zhangling Wang、Yongluo Jiang、Xuan Miao、Yixuan Yan、Hailin Tang、Lewei Zhu、Yutian Zou、Peng Liu

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State Key Laboratory of Oncology in South China,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou 510060,China

School of Medicine,Sun Yat-sen University,Shenzhen 518107,China

Key Laboratory of Cardiovascular and Cerebrovascular Medicine,Nanjing Medical University,Nanjing 211166,China

Guanghua School of Stomatology,Sun Yat-sen University,Guangzhou 510062,China

The First People's Hospital of Foshan,Foshan 528000,China

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Basic and Applied Basic Research Foundation of Guangdong Province广东省自然科学基金

2022A15152201842021A1515010547

2024

10.1007/s11427-023-2491-7

中国科学:生命科学(英文版)
中国科学院

中国科学:生命科学(英文版)

CSTPCD
影响因子：0.806
ISSN：1674-7305
年,卷(期)：2024.67(4)
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