首页|Slc43a2+T cell metastasis from spleen to brain in RGNNV infected teleost

Slc43a2+T cell metastasis from spleen to brain in RGNNV infected teleost

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The origin of T cells in the teleost's brain is unclear.While viewing the central nervous system(CNS)as immune privileged has been widely accepted,previous studies suggest that T cells residing in the thymus but not in the spleen of the teleost play an essential role in communicating with the peripheral organs.Here,we identified nine T cell subpopulations in the thymus and spleen of orange-spotted grouper(Epinephelus coioices)through single-cell RNA-sequencing analysis.After viral CNS infection with red-spotted grouper nervous necrosis virus(RGNNV),the number of slc43a2+T cells synchronously increased in the spleen and brain.During the infection tests in asplenic zebrafish(tlx1▲ zebrafish model),no increase in the number of slc43a2+T cells was observed in the brain.Single-cell tran-scriptomic analysis indicated that slc43a2+T cells mature and functionally differentiate within the spleen and then migrate into the brain to trigger an immune response.This study suggests a novel route for T cell migration from the spleen to the brain during viral infection in fish.

central nervous systemslc43a2+T cellRGNNVT cell migrationteleost

Qing Wang、Yali Liu、Minlin Zhang、Min Yang、Jiantao Liang、Xiaoling Zuo、Shaowen Wang、Xianze Jia、Huihong Zhao、Han Jiang、Qiang Lin、Qiwei Qin

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College of Marine Sciences,South China Agricultural University,Guangzhou 510642,China

Nansha-South China Agricultural University Fishery Research Institute,Guangzhou 511457,China

Joint University Laboratory of Guangdong Province,Hong Kong and Marco Region on Marine Bioresource Conservation and Exploitation,Guangzhou 510642,China

CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China

University of Chinese Academy of Sciences,Beijing 100101,China

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国家重点研发计划国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金广东省自然科学基金Key-Area Research and Development Program of Guangdong Province现代农业产业技术体系建设项目

2022YFD2400502421761034182501342230409422761272022A15150125052021B0202040002CARS-47-G16

2024

10.1007/s11427-023-2473-x

中国科学:生命科学(英文版)
中国科学院

中国科学:生命科学(英文版)

CSTPCD
影响因子：0.806
ISSN：1674-7305
年,卷(期)：2024.67(4)
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