首页|When smoke meets gut:deciphering the interactions between tobacco smoking and gut microbiota in disease development

When smoke meets gut:deciphering the interactions between tobacco smoking and gut microbiota in disease development

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Tobacco smoking is a prevalent and detrimental habit practiced worldwide,increasing the risk of various diseases,including chronic obstructive pulmonary disease(COPD),cardiovascular disease,liver disease,and cancer.Although previous research has explored the detrimental health effects of tobacco smoking,recent studies suggest that gut microbiota dysbiosis may play a critical role in these outcomes.Numerous tobacco smoke components,such as nicotine,are found in the gastrointestinal tract and interact with gut microbiota,leading to lasting impacts on host health and diseases.This review delves into the ways tobacco smoking and its various constituents influence gut microbiota composition and functionality.We also summarize recent advancements in understanding how tobacco smoking-induced gut microbiota dysbiosis affects host health.Furthermore,this review introduces a novel perspective on how changes in gut microbiota following smoking cessation may contribute to withdrawal syndrome and the degree of health improvements in smokers.

tobacco smokinggut microbiota dysbiosisnicotinesmoking cessation

Bo Chen、Guangyi Zeng、Lulu Sun、Changtao Jiang

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Center of Basic Medical Research,Institute of Medical Innovation and Research,Peking University Third Hospital,Beijing 100191,China

Department of Physiology and Pathophysiology,School of Basic Medical Sciences,State Key Laboratory of Vascular Homeostasis and Remodeling,Peking University,Beijing 100191,China

Center for Obesity and Metabolic Disease Research,School of Basic Medical Sciences,Peking University,Beijing 100191,China

tate Key Laboratory of Women's Reproductive Health and Fertility Promotion,Peking University,Beijing 100191,China

Department of Endocrinology and Metabolism,Peking University Third Hospital,Beijing 100191,China

tate Key Laboratory of Women's Reproductive Health and Fertility Promotion,Peking

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaNational Key Research and Development Program of China

31925021821300222018YFA08007002022YFA0806403

2024

10.1007/s11427-023-2446-y

中国科学:生命科学(英文版)
中国科学院

中国科学:生命科学(英文版)

CSTPCD
影响因子：0.806
ISSN：1674-7305
年,卷(期)：2024.67(5)