首页|Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis
Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
万方数据
维普
Bile acids(BAs)play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune home-ostasis.Through the enterohepatic circulation,BAs are synthesized,metabolized,and reabsorbed,with a portion entering the vascular circulation and distributing systemically.This allows BAs to interact with receptors in all major organs,leading to organ-organ interactions that regulate both local and global metabolic processes,as well as the immune system.This review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation,including in the brain,heart,liver,intestine,eyes,skin,adipose tissue,and muscle.Targeting BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.
School of Chinese Medicine,Hong Kong Baptist University,Hong Kong,China
Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China
National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaShanghai Research Center for Endocrine and Metabolic Diseases
万方数据
维普
