Exercise-induced microbial changes in preventing type 2 diabetes

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外文摘要：The metabolic benefits associated with long-term physical activity are well appreciated and growing evidence suggests that it involves the gut microbiota.Here we re-evaluated the link between exercise-induced microbial changes and those associated with prediabetes and diabetes.We found that the relative abundances of substantial amounts of diabetes-associated metagenomic species associated negatively with physical fitness in a Chinese athlete students cohort.We additionally showed that those microbial changes correlated more with handgrip strength,a simple but valuable biomarker suggestive of the diabetes states,than maximum oxygen intake,one of the key surrogates for endurance training.Moreover,the causal relationships among exercise,risks for diabetes,and gut microbiota were explored based on mediation analysis.We propose that the protective roles of exercise against type 2 diabetes are mediated,at least partly,by the gut microbiota.

外文关键词：

gut microbiotabody fatdiabeteshandgripmaximum oxygen intake

作者：

Ting Yao、Hui Wang、Kaiqing Lin、Ruwen Wang、Shanshan Guo、Peijie Chen、Hao Wu、Tiemin Liu、Ru Wang

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作者单位：

School of Exercise and Health,Shanghai Frontiers Science Research Base of Exercise and Metabolic Health,Shanghai University of Sport,Shanghai 200438,China

Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Xi'an Jiaotong University School of Medicine,Xi'an 710061,China

Shanghai Key Laboratory of Metabolic Remodeling and Health,Institute of Metabolism & Integrative Biology,Fudan University,Shanghai 200433,China

State Key Laboratory of Genetic Engineering,Human Phenome Institute,Fudan Microbiome Center,and Department of Bariatric and Metabolic Surgery,Huashan Hospital,Fudan University,Shanghai 201203,China

State Key Laboratory of Genetic Engineering,Department of Endocrinology and Metabolism,Human Phenome Institute,and School of Life Sciences,Zhongshan Hospital,Fudan University,Shanghai 200032,China

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基金：

National Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaInnovation Team and Talents Cultivation Program of National Administration of Traditional Chinese MedicineShanghai Frontiers Science Research Base of Exercise and Metabolic HealthConstruction Project of High-Level Local Universities in ShanghaiShanghai"Science and Technology Innovation Action Plan"Social Development Science and Technology Reach ProjectShanghai Municipal Science and Technology Major Project

项目编号：

31971097316712423215061047531971074ZYYCXTD-D-20200122dz12046002017SHZDZX01

出版年：

2024

DOI：

10.1007/s11427-022-2272-3

中国科学:生命科学(英文版)

中国科学院

中国科学:生命科学(英文版)

CSTPCD

影响因子：0.806

ISSN：1674-7305

年,卷(期)：2024.67(5)