Role of adhesion molecules in cancer and targeted therapy

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外文摘要：Adhesion molecules mediate cell-to-cell and cell-to-extracellular matrix interactions and transmit mechanical and chemical signals among them.Various mechanisms deregulate adhesion molecules in cancer,enabling tumor cells to proliferate without restraint,invade through tissue boundaries,escape from immune surveillance,and survive in the tumor microenvironment.Recent studies have revealed that adhesion molecules also drive angiogenesis,reshape metabolism,and are involved in stem cell self-renewal.In this review,we summarize the functions and mechanisms of adhesion molecules in cancer and the tumor microenvironment,as well as the therapeutic strategies targeting adhesion molecules.These studies have implications for furthering our understanding of adhesion molecules in cancer and providing a paradigm for exploring novel therapeutic approaches.

外文关键词：

adhesion moleculestumor microenvironmentinvasion and metastasisreshaping metabolismangiogenesisimmune evasiontumor stemnesstherapeutic strategy

作者：

Chunmei Fan、Fang Xiong、Shanshan Zhang、Zhaojian Gong、Qianjin Liao、Guiyuan Li、Can Guo、Wei Xiong、He Huang、Zhaoyang Zeng

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作者单位：

NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism,Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410000,China

Department of Histology and Embryology,Xiangya School of Medicine,Central South University,Changsha,410013,China

Department of Stomatology,Xiangya Hospital,Central South University,Changsha 410078,China

Department of Oral and Maxillofacial Surgery,The Second Xiangya Hospital,Central South University,Changsha 410011,China

Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education,Cancer Research Institute,Central South University,Changsha 410078,China

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基金：

National Natural Science Foundation of ChinaNatural Science Foundation of Hunan ProvinceNatural Science Foundation of ChangshaYoung Elite Scientists Sponsorship Program by CAST

项目编号：

822031632022JJ40660kq22021232022QNRC001

出版年：

2024

DOI：

10.1007/s11427-023-2417-3

中国科学:生命科学(英文版)

中国科学院

中国科学:生命科学(英文版)

CSTPCD

影响因子：0.806

ISSN：1674-7305

年,卷(期)：2024.67(5)