Ferroptosis:a critical mechanism of N6-methyladenosine mod-ification involved in carcinogenesis and tumor progression

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外文摘要：Ferroptosis is an iron-dependent regulatory cell necrosis induced by iron overload and lipid peroxidation.It occurs when multiple redox-active enzymes are ectopically expressed or show abnormal function.Hence,the precise regulation of ferroptosis-related molecules is mediated across multiple levels,including transcriptional,posttranscriptional,translational,and epigenetic levels.N6-methyladenosine(m6 A)is a highly evolutionarily conserved epigenetic modification in mammals.The m6A modification is commonly linked to tumor pro-liferation,progression,and therapy resistance because it is involved in RNA metabolic processes.Intriguingly,accumulating evidence suggests that dysregulated ferroptosis caused by the m6A modification drives tumor development.In this review,we summarized the roles of m6A regulators in ferroptosis-mediated malignant tumor progression and outlined the m6A regulatory mechanism involved in ferroptosis pathways.We also analyzed the potential value and application strategies of targeting m6A/ferroptosis pathway in the clinical diagnosis and therapy of tumors.

外文关键词：

ferroptosism6A modificationRNA methylationm6A regulatortumor progression

作者：

Qingqing Wei、Changning Xue、Mengna Li、Jianxia Wei、Lemei Zheng、Shipeng Chen、Yumei Duan、Hongyu Deng、Faqing Tang、Wei Xiong、Ming Zhou

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作者单位：

NHC Key Laboratory of Carcinogenesis,Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410013,China

Cancer Research Institute and School of Basic Medical Sciences,Central South University,Changsha 410078,China

The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education,Central South University,Changsha 410078,China

Hunan Key Laboratory of Oncotarget Gene,Hunan Key Laboratory of Cancer Metabolism,Hunan Ca

Hunan Key Laboratory of Oncotarget Gene,Hunan Key Laboratory of Cancer Metabolism,Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410013,China

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基金：

National Natural Science Foundation of ChinaFree Exploration Program of Central South Universityprogram of Introducing Talents of Discipline to Universities

项目编号：

821725922021zzts0934111-2-12

出版年：

2024

DOI：

10.1007/s11427-023-2474-4

中国科学:生命科学(英文版)

中国科学院

中国科学:生命科学(英文版)

CSTPCD

影响因子：0.806

ISSN：1674-7305

年,卷(期)：2024.67(6)

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