首页|A neural m6A pathway regulates behavioral aggregation in migratory locusts

A neural m6A pathway regulates behavioral aggregation in migratory locusts

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
RNA N6-methyladenosine(m6A),as the most abundant modification of messenger RNA,can modulate insect behaviors,but its specific roles in aggregation behaviors remain unexplored.Here,we conducted a comprehensive molecular and physiological characterization of the individual components of the methyltransferase and demethylase in the migratory locust Locusta migratoria.Our results demonstrated that METTL3,METTL14 and ALKBH5 were dominantly expressed in the brain and exhibited remarkable responses to crowding or isolation.The individual knockdown of methyltransferases(i.e.,METTL3 and METTL14)promoted locust movement and conspecific attraction,whereas ALKBH5 knockdown induced a behavioral shift toward the solitary phase.Furthermore,global transcriptome profiles revealed that m6A modification could regulate the orchestration of gene expression to fine tune the behavioral aggregation of locusts.In summary,our in vivo characterization of the m6A functions in migratory locusts clearly demonstrated the crucial roles of the m6A pathway in effectively modulating aggregation behaviors.

RNA methylationN6-methyladenosinetranscriptional orchestrationaggregation behaviorLocusta migratoria

Xianliang Huang、Qing Li、Yanan Xu、Ang Li、Shanzheng Wang、Yusheng Chen、Chunrui Zhang、Xia Zhang、Hailin Wang、Cong Lv、Baofa Sun、Shaoqin Li、Le Kang、Bing Chen

展开 >

School of Life Science,Institutes of Life Science and Green Development,Hebei University,Baoding 071002,China

College of Plant Science and Technology,Huazhong Agricultural University,Wuhan 430070,China

State Key Laboratory of Integrated Management of Pest Insects and Rodents,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China

Institute of Health Sciences,Anhui University,Hefei 230601,China

Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China

State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing,100101,China

展开 >

National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaHebei Natural Science FoundationHebei Natural Science FoundationHebei Educational Committee Foundation

2022YFD140050332102208C2022201042C2023201075BJK2023015

2024

10.1007/s11427-023-2476-1

中国科学:生命科学(英文版)
中国科学院

中国科学:生命科学(英文版)

CSTPCD
影响因子：0.806
ISSN：1674-7305
年,卷(期)：2024.67(6)
  • 94