首页|Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

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Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban environments.To address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the MetaSUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based methodology.Our findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical conditions.We also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel antibiotics.Our study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

urban environmentmetagenomeantibiotic resistanceresistance diversitybiosynthetic gene clusters

Jun Wu、Yige Hu、Michael H Perlin、David Danko、Jun Lu、Manuela Oliveira、Johannes Werner、Maria M Zambrano、Maria A Sierra、Olayinka O Osuolale、Pawe? ?abaj、Nicolás Rascovan、Nur Hazlin Hazrin-Chong、Soojin Jang、Haruo Suzuki、Marina Nieto-Caballero、Bharath Prithiviraj、Patrick K H Lee、Agnieszka Chmielarczyk、Anna Ró?ańska、Yongxiang Zhao、Lan Wang、Christopher E Mason、Tieliu Shi

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Center for Bioinformatics and Computational Biology,and the Institute of Biomedical Sciences,School of Life Sciences,East China Normal University,Shanghai 200241,China

Department of Biology,Program on Disease Evolution,University of Louisville,Louisville 40292,USA

Weill Cornell Medicine,New York 10065,USA

The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine,New York 10065,USA

Department of Pulmonary Medicine,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200025,China

i3S-Instituto de Investigação e Inovaçao em Saúde,Universidade do Porto,Porto 4050-290,Portugal

Ipatimup-Instituto de Patologia e Imunologia Molecular da Universidade do Porto,Porto 4200-465,Portugal

Departamento de Blologia,Faculdade de Ciências,Universidade do Porto,Porto 4050-290,Portugal

High Performance and Cloud Computing Group,Zentrum für Datenverarbeitung(ZDV),Eberhard Karls University of Tübingen,Wächterstraße 76,72074,Tübingen,Germany

Corporación Corpogen Research Center,Bogotá 110311,Colombia

Applied Environmental Metagenomics and Infectious Diseases Research(AEMIDR),Department of Biological Sciences,Elizade University,llara-Mokin 340271,Nigeria

Maopolska Centre of Biotechnology,Jagiellonian University,Krak6w 30-005,Poland

Aix-Marseille Université,Mediterranean Institute of Oceanology,Université de Toulon,CNRS,IRD,UM 110,Marseille 83041,France

Department of Biological Sciences and Biotechnology,Faculty of Science and Technology,Universiti Kebangsaan Malaysia,43600 UKM Bangi,Selangor

Institut Pasteur Korea,Seoul 13488,Republic of Korea

Faculty of Environment and Information Studies,Keio University,Fujisawa,Kanagawa 252-0882,Japan

University of Colorado at Boulder,Civil,Environmental and Architectural Department,Boulder 80303,USA

Brooklyn College of the City University of New York,Brooklyn 11210,USA

School of Energy and Environment,City University of Hong Kong,Hong Kong 999077,China

Department of Microbiology,Faculty of Medicine,Jagiellonian University,Kraków 30-005,Poland

Biological Targeting Diagnosis and Therapy Research Center,Guangxi Medical University,Nanning 530021,China

College of Architecture and Urban Planning,Tongji University,Shanghai 200092,China

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National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaBeihang University & Capital Medical University PlanOpen Research Fund of Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE,ECNUKey Laboratory of MEA,Ministry of Education,ECNUKey Laboratory of Ecology and Energy Saving Study of Dense Habitat(Tongji University)Ministry of Education-Shanghai Tongji Urban Planning & Design Institute Co.,Ltd Joint Research ProjectShanghai Tongji Urban Planning & Design Institute Co.,Ltd-China Intelligent Urbanization Cocreation Center for High Density RegiEpigenomics Core Facility at Weill Cornell MedicineScientific Computing Unit(SCU),XSEDE Supercomputing ResourcesIrma T.Hirechl and Monique Weill-Caulier Charitable TrustsBert L and N Kuggie Vallee FoundationWorldQuant FoundationPershing Square Sohn Cancer Research AllianceNational Institutes of HealthNational Science FoundationAlfred P.Sloan Foundation

2023YFC270650332370720BHME-201904KY-2022-LH-A03KY-2022-PT-A02R01AI1510591840275G-2015-13964

2024

10.1007/s11427-023-2504-1

中国科学:生命科学(英文版)
中国科学院

中国科学:生命科学(英文版)

CSTPCD
影响因子：0.806
ISSN：1674-7305
年,卷(期)：2024.67(6)
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