Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE,State Key Laboratory of Biotherapy,West China Second University Hospital,Sichuan University,Chengdu 610041,China

Guangdong Institute of Gastroenterology,Department of General Surgery,Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases,The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou 510655,China

Department of Molecular Biology and Biochemistry,Institute of Basic Medical Sciences,Medical Primate Research Center,Neuroscience Center,Chinese Academy of Medical Sciences,School of Basic Medicine Peking Union Medical College,Beijing 100730,China

State Key Laboratory of Respiratory Health and Multimorbidity,Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine Peking Union Medical College,Beijing 100730,China

Institute of Laboratory Animal Science,Chinese Academy