首页|CD146,a therapeutic target involved in cell plasticity
CD146,a therapeutic target involved in cell plasticity
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Since its identification as a marker for advanced melanoma in the 1980s,CD146 has been found to have multiple functions in both physiological and pathological processes,including embryonic development,tissue repair and regeneration,tumor progression,fibrosis disease,and inflammations.Subsequent research has revealed that CD146 is involved in various signaling pathways as a receptor or co-receptor in these processes.This correlation between CD146 and multiple diseases has sparked interest in its potential applications in diagnosis,prognosis,and targeted therapy.To better comprehend the versatile roles of CD146,we have summarized its research history and synthesized findings from numerous reports,proposing that cell plasticity serves as the underlying mechanism through which CD146 contributes to development,regeneration,and various diseases.Targeting CD146 would consequently halt cell state shifting during the onset and progression of these related diseases.Therefore,the development of therapy targeting CD 146 holds significant practical value.
CAS Engineering Laboratory for Nanozyme,Key Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China
College of Life Sciences,University of Chinese Academy of Sciences,Beijing 100049,China
Nanozyme Laboratory in Zhongyuan,Henan Academy of Innovations in Medical Science,Zhengzhou 451163,China
Joint Laboratory of Nanozymes in Zhengzhou University,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001,China
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Beijing Natural Science Foundation of ChinaBeijing Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaChina Postdoctoral Science Foundation
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