首页|High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirty-six patients with ITP and nine healthy volunteers were enrolled in the study.As soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP patients.On the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upre-gulated in mainly central memory and effector T cells.In contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th1 7 cell subsets.Taking a platelet count of 30×109 L-1 as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune profiles.Antigen-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of ITP.In conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of ITP.They may offer novel targets to develop personalized immunotherapies.

immune thrombocytopeniaautoimmune diseasesco-stimulatoryco-inhibitoryimmune checkpointCTLA4Cytometry by Time of Flightbone marrow

Feng-Qi Liu、Qing-Yuan Qu、Ying Lei、Qi Chen、Yu-Xiu Chen、Meng-Lin Li、Xue-Yan Sun、Ye-Jun Wu、Qiu-Sha Huang、Hai-Xia Fu、Yuan Kong、Yue-Ying Li、Qian-Fei Wang、Xiao-Jun Huang、Xiao-Hui Zhang

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Peking University People's Hospital,Peking University Institute of Hematology,Beijing 100044,China

Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Beijing 100044,China

National Clinical Research Center for Hematologic Disease,Beijing 100044,China

Collaborative Innovation Centre of Hematology,Peking University,Beijing 100044,China

CAS Key Laboratory of Genomic and Precision Medicine,Beijing Institute of Genomics,Chinese Academy of Sciences and China National Center for Bioinformation,Beijing 100101,China

University of Chinese Academy of Sciences,Beijing 100049,China

Peking-Tsinghua Center for Life Sciences,Academy for Advanced Interdisciplinary Studies,Peking University,Beijing 100074,China

State Key Laboratory of Natural and

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaCapital Health Research and Development of SpecialPeking University Medicine Fund for world's leading discipline or discipline cluster development

8223000481970113823001492021YFC25003042022-1-408271003Y3035

2024

10.1007/s11427-023-2520-4

中国科学:生命科学(英文版)
中国科学院

中国科学:生命科学(英文版)

CSTPCD
影响因子：0.806
ISSN：1674-7305
年,卷(期)：2024.67(8)
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