Dynamic intrauterine crosstalk promotes porcine embryo implantation during early pregnancy

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外文摘要：Dynamic crosstalk between the embryo and mother is crucial during implantation.Here,we comprehensively profile the single-cell tran-scriptome of pig peri-implantation embryos and corresponding maternal endometrium,identifying 4 different lineages in embryos and 13 cell types in the endometrium.Cell-specific gene expression characterizes 4 distinct trophectoderm subpopulations,showing development from undifferentiated trophectoderm to polar and mural trophectoderm.Dynamic expression of genes in different types of endometrial cells illustrates their molecular response to embryos during implantation.Then,we developed a novel tool,ExtraCellTalk,generating an overall dynamic map of maternal-foetal crosstalk using uterine luminal proteins as bridges.Through cross-species comparisons,we identified a conserved RBP4/STRA6 pathway in which embryonic-derived RBP4 could target the STRA6 receptor on stromal cells to regulate the interaction with other endometrial cells.These results provide insight into the maternal-foetal crosstalk during embryo implantation and represent a valuable resource for further studies to improve embryo implantation.

外文关键词：

endometrial remodelingExtraCellTalkimplantationmaternal-foetal crosstalktrophoblast

作者：

Xupeng Zang、Shengchen Gu、Wenjing Wang、Junsong Shi、Jianyu Gan、Qun Hu、Chen Zhou、Yue Ding、Yanjuan He、Lei Jiang、Ting Gu、Zheng Xu、Sixiu Huang、Huaqiang Yang、Fanming Meng、Zicong Li、Gengyuan Cai、Linjun Hong、Zhenfang Wu

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作者单位：

State Key Laboratory of Swine and Poultry Breeding Industry,National Engineering Research Center for Breeding Swine Industry,College of Animal Science,South China Agricultural University,Guangzhou 510642,China

Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding,South China Agricultural University,Guangzhou 510642,China

Yunfu Subcenter of Guangdong Laboratory for Lingnan Modern Agriculture,Yunfu 527300,China

Key Laboratory of South China Modern Biological Seed Industry,Ministiy of Agriculture and Rural Affairs,Guangzhou 510520,China

Guangdong Key Laboratory of Animal Breeding and Nutrition,Institute of Animal Science,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China

Key Laboratory of South China Modern Biological Seed Industry,Ministiy

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基金：

National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaGuangdong Provincial Key Area Research and Development ProgramGuangdong Basic and Applied Basic Research FoundationGuangdong Basic and Applied Basic Research FoundationGuangdong Provincial Promotion Project on Preservation and Utilization of Local Breed of Livestock and Poultry

项目编号：

2021YFD1301103318020332022B02020900022022A15150111312023A15150301932018143

出版年：

2024

DOI：

10.1007/s11427-023-2557-x

中国科学:生命科学(英文版)

中国科学院

中国科学:生命科学(英文版)

CSTPCD

影响因子：0.806

ISSN：1674-7305

年,卷(期)：2024.67(8)

参考文献量2