The genetic basis and process of inbreeding depression in an elite hybrid rice

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外文摘要：Inbreeding depression refers to the reduced performance arising from increased homozygosity,a phenomenon that is the reverse of heterosis and exists among plants and animals.As a natural self-pollinated crop with strong heterosis,the mechanism of inbreeding depression in rice is largely unknown.To understand the genetic basis of inbreeding depression,we constructed a successive inbreeding population from the F2 to F4 generation and observed inbreeding depression of all heterotic traits in the progeny along with the decay of heterozygosity in each generation.The expected depression effect was largely explained by 13 QTLs showing dominant effects for spikelets per panicle,11 for primary branches,and 12 for secondary branches,and these loci constitute the main correlation between heterosis and inbreeding depression.However,the genetic basis of inbreeding depression is also distinct from that of heterosis,such that a biased transmission ratio of alleles for QTLs with either dominant or additive effects in four segregation distortion regions would result in minor effects in expected depression.Noticeably,two-locus interactions may change the extent and direction of the depression effects of the target loci,and overall interactions would promote inbreeding depression among generations.Using an F2∶3 variation population,the actual performance of the loci showing expected depression was evaluated considering the heterozygosity decay in the background after in-breeding.We found inconsistent or various degrees of background depression from the F2 to F3 generation assuming different genotypes of the target locus,which may affect the actual depression effect of the locus due to epistasis.The results suggest that the genetic architecture of inbreeding depression and heterosis is closely linked but also differs in their intrinsic mechanisms,which expand our understanding of the whole-genome architecture of inbreeding depression.

外文关键词：

riceinbreeding depressionspikelet developmentdominancesegregation distortionepistasis

作者：

Xiaodong Xu、Yawen Xu、Jian Che、Xu Han、Zhengji Wang、Xianmeng Wang、Qinghua Zhang、Xu Li、Qinglu Zhang、Jinghua Xiao、Xianghua Li、Qifa Zhang、Yidan Ouyang

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作者单位：

National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research(Wuhan),Hubei Hongshan Laboratory,Huazhong Agricultural University,Wuhan 430070,China

基金：

National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaHubei Key R&D ProgramHubei Key R&D Program in Hongshan LabHubei Key R&D Program in Hongshan LabFundamental Research Founds for the Central Universities

项目编号：

2022YFF1002100319912233234103132170622318210052020BBA0342021hszd0052022hszd0172662023PY002

出版年：

2024

DOI：

10.1007/s11427-023-2547-2

中国科学:生命科学(英文版)

中国科学院

中国科学:生命科学(英文版)

CSTPCD

影响因子：0.806

ISSN：1674-7305

年,卷(期)：2024.67(8)