Biomolecular condensates and disease pathogenesis

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外文摘要：Biomolecular condensates or membraneless organelles(MLOs)formed by liquid-liquid phase separation(LLPS)divide intracellular spaces into discrete compartments for specific functions.Dysregulation of LLPS or aberrant phase transition that disturbs the formation or material states of MLOs is closely correlated with neurodegeneration,tumorigenesis,and many other pathological processes.Herein,we summarize the recent progress in development of methods to monitor phase separation and we discuss the biogenesis and function of MLOs formed through phase separation.We then present emerging proof-of-concept examples regarding the disruption of phase separation homeostasis in a diverse array of clinical conditions including neurodegenerative disorders,hearing loss,cancers,and immunological diseases.Finally,we describe the emerging discovery of chemical modulators of phase separation.

外文关键词：

liquid-liquid phase separationbiomolecular condensatemembraneless organelle

作者：

Ke Ruan、Ge Bai、Yanshan Fang、Dan Li、Tingting Li、Xingguo Liu、Boxun Lu、Qing Lu、Zhou Songyang、Shuguo Sun、Zheng Wang、Xin Zhang、Wen Zhou、Hong Zhang

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作者单位：

The First Affiliated Hospital & School of Life Sciences,Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics,Hefei National Research Center for Interdisciplinary Sciences at the Microscale,Center for Advanced Interdisciplinary Science and Biomedicine of IHM,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230027,China

Nanhu Brain-computer Interface Institute,Hangzhou 311100,China

Department of Neurology of Second Affiliated Hospital and School of Brain Science and Brain Medicine,Zhejiang University School of Medicine,Hangzhou 310058,China

Interdisciplinary Research Center on Biology and Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 201210,China

University of Chinese Academy of Sciences,Beijing 100049,China

Bio-X Institutes,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education),Shanghai Jiao Tong University,Shanghai 200030,China

Department of Biomedical Informatics,School of Basic Medical Sciences,Peking University Health Science Center,Beijing 100191,China

CAS Key Laboratory of Regenerative Biology,Joint School of Life Sciences,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou 510530,China

Joint School of Life Sciences,Guangzhou Medical University,Guangzhou 510000,China

Neurology Department at Huashan Hospital,State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Institutes of Brain Science,School of Life Sciences,Fudan University,Shanghai 200433 China

Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders,Ministry of Education,Bio-X Institutes,Shanghai Jiao Tong University,Shanghai 200030,China

State Key Laboratory of Biocontrol,MOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging Research,School of Life Sciences,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510275,China

Department of Human Anatomy,Histology and Embryology,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

The Second Affiliated Hospital,School of Basic Medical Sciences,Institute of Biomedical Innovation,Jiangxi Medical College,Nanchang University,Nanchang 330031,China

Westlake Laboratory of Life Sciences and Biomedicine,Hangzhou 310024,China

Department of Immunology and Microbiology,School of Life Sciences,Southern University of Science and Technology,Shenzhen 518055,China

National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China

College of Life Sciences,University of Chinese Academy of Sciences,Beijing 100049,China

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基金：

Strategic Priority Research Program of the Chinese Academy of SciencesNational Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaSTI2030-Major ProjectsScience and Technology Commission of Shanghai MunicipalityScience and Technology Commission of Shanghai MunicipalityKey Research Program CASInternational Cooperation Program CASCAS Project for Young Scientists in Basic ResearchGuangdong Province Science and Technology ProgramGuangdong Province Science and Technology ProgramNatural Science Foundation of Anhui ProvinceCenter for Advanced Interdisciplinary Science and Biomedicine of IHMShenzhen Talent ProgramGuangdong Innovative and Entrepreneurial Research Team Program

项目编号：

XDB04800002022YFA11038002022YFA13031002023YFE02101002233700522377119320250103224100232270812322709203232501632350024322611603768215000382188102021ZD02025012019SHZDZX0220490712600ZDBS-ZRKJZ-TLC003154144KYSB20200006YSBR-0752023B11110500052023B12120600502108085J12QYPY20220008KQTD202108110901150212021ZT09Y104

出版年：

2024

DOI：

10.1007/s11427-024-2661-3

中国科学:生命科学(英文版)

中国科学院

中国科学:生命科学(英文版)

CSTPCD

影响因子：0.806

ISSN：1674-7305

年,卷(期)：2024.67(9)