首页|Early-onset and later-onset cancer:trends,risk factors,and prevention in Northern China

Early-onset and later-onset cancer:trends,risk factors,and prevention in Northern China

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The characteristics of early-onset(onset age＜50 years)and later-onset(onset age ≥ 50 years)cancers differ significantly.Identifying novel risk factors for both types of cancer is crucial for increasing awareness of cancer prevention and for reducing its burden.This study aimed to analyze the trends in incidence and risk factors for early-onset and late-onset cancers.We conducted a prospective study by drawing data from the Kailuan Study.This study included 6,741 participants with cancer(624 with early-onset cancer and 6,117 with later-onset cancer)and 6,780 matched controls among the 186,249 participants who underwent Kailuan health examinations from 2006 to 2019.The primary outcomes were cancer incidence rates,and associated risk factors for early-and later-onset cancer.Weighted Cox regression was used to calculate hazard ratios and 95％confidence intervals of each exposure factor for early-and later-onset cancer by cancer type.Population-attributable risk proportions were used to estimate the number of cases that could be prevented by eliminating a risk factor from the population.Except for liver cancer,incidence rates for nearly all types of cancer increased during the study period.Smoking,alcohol consumption,lipid metabolism disorders,hypertension,diabetes mellitus,fatty liver,and inflammation were associated with a significantly increased risk of cancer at multiple sites,but risk factors for cancer incidence differed by site.Smoking,alcohol consumption,inflammation,and hypertension were the major contributors to preventable cancer.The incidence of several different types of cancer,including early-onset cancer,is increasing in northeastern China.Differences in risk factors between early-onset and later-onset malignancies may con-tribute to the divergence in the observed changes in incidence trends between these two specific types of cancer.

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Tong Liu、Chen-An Liu、Qing-Song Zhang、Qi Zhang、Yi-Ming Wang、Meng-Meng Song、Shi-Qi Lin、Li Deng、Shou-Ling Wu、Han-Ping Shi

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Department of Gastrointestinal Surgery,Department of Clinical Nutrition,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China

National Clinical Research Center for Geriatric Diseases,Xuanwu Hospital,Capital Medical University,Beijing 100053,China

Key Laboratory of Cancer FSMP for State Market Regulation,Beijing 100038,China

Laboratory for Clinical Medicine,Capital Medical University,Beijing 100038,China

Department of General Surgery,Kailuan General Hospital,Tangshan 063000,China

Department of Genetics,Yale School of Medicine,New Haven 06510,USA

Department of Hepatobiliary Surgery,Kailuan General Hospital,Tangshan 063000,China

Cardiovascular Research Institute,University of California,San Francisco 94158,USA

Department of Cardiology,Kailuan General Hospital,Tangshan 063000,China

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National Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaJiangxi Province Science Foundation for Youths

2022YFC20096002022YFC200960120161BAB215187

2024

10.1007/s11427-023-2523-5

中国科学:生命科学(英文版)
中国科学院

中国科学:生命科学(英文版)

CSTPCD
影响因子：0.806
ISSN：1674-7305
年,卷(期)：2024.67(9)