Genomic insights into adaptation to bipedal saltation and desert-like habitats of jerboas

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外文摘要：Jerboas is a lineage of small rodents displaying atypical mouse-like morphology with elongated strong hindlimbs and short forelimbs.They have evolved obligate bipedal saltation and acute senses,and been well-adapted to vast desert-like habitats.Using a newly sequenced chromosome-scale genome of the Mongolian five-toed jerboa(Orientallactaga sibirica),our comparative genomic analyses and in vitro functional assays showed that the genetic innovations in both protein-coding and non-coding regions played an important role in jerboa morphological and physiological adaptation.Jerboa-specific amino acid substitutions,and segment insertions/deletions(indels)in con-served non-coding elements(CNEs)were found in components of proteoglycan biosynthesis pathway(XYLT1 and CHSY1),which plays an important role in limb development.Meanwhile,we found specific evolutionary changes functionally associated with energy or water metabolism(e.g.,specific amino acid substitutions in ND5 and indels in CNEs physically near ROR2)and senses(e.g.,expansion of vo-meronasal receptors and the FAM136A gene family)in jerboas.Further dual-luciferase reporter assay verified that some of the CNEs with jerboa-specific segment indels exerted a significantly different influence on luciferase activity,suggesting changes in their regulatory function in jerboas.Our results revealed the potential molecular mechanisms underlying jerboa adaptation since the divergence from the Eocene-Oligocene transition,and provided more resources and new insights to enhance our understanding of the molecular basis under-lying the phenotypic diversity and the environmental adaptation of mammals.

外文关键词：

jerboaadaptive evolutioncomparative genomicsconserved non-coding elementsbipedal saltation

作者：

Simin Chai、Yujie Chong、Daiqing Yin、Qiang Qiu、Shixia Xu、Guang Yang

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作者单位：

Southem Marine Science and Engineering Guangdong Laboratory(Guangzhou),Guangzhou 511458,China

Jiangsu Key Laboratory for Biodiversity and Biotechnology,School of Life Sciences,Nanjing Normal University,Nanjing 210023,China

School of Ecology and Environment,Northwestern Polytechnical University,Xi'an 710072,China

基金：

Youth Fund of the National Natural Science Foundation of ChinaChina Postdoctoral Science FoundationNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaKey Project of the National Natural Science Foundation of ChinaPI Project of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)

项目编号：

322003452022M71087832270453322704423177244832030011GML2021GD0805

出版年：

2024

DOI：

10.1007/s11427-023-2516-9

中国科学:生命科学(英文版)

中国科学院

中国科学:生命科学(英文版)

CSTPCD

影响因子：0.806

ISSN：1674-7305

年,卷(期)：2024.67(9)