Recent progress on the underlying biological mechanisms of healthy longevity has propelled the field from elucidating genetic modification of healthy longevity hallmarks to defining mechanisms of gut microbiota influencing it.Importantly,the role of gut microbiota in the healthy longevity of the host may provide unprecedented opportunities to decipher the plasticity of lifespan on a natural evolutionary scale and shed light on using microbiota-targeted strategies to promote healthy aging and combat age-related diseases.This review investigates how gut microbiota affects healthy longevity,focusing on the mechanisms through which gut microbiota modulates it.Specifically,we focused on the ability of gut microbiota to enhance the intestinal barrier integrity,provide protection from inflammaging,ameliorate nutrientsensing pathways,optimize mitochondrial function,and improve defense against age-related diseases,thus participating in en-hancing longevity and healthspan.
gut microbiotalongevityhealthy agingshort-chain fatty acidstryptophan metabolitesbile acids
Jia Luo、Shan Liang、Feng Jin
展开 >
College of Psychology,Sichuan Normal University,Chengdu 610066,China
Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China
万方数据
维普
