首页|Individual and joint exposures to PM2.5 constituents and mortality risk among the oldest-old in China

Individual and joint exposures to PM2.5 constituents and mortality risk among the oldest-old in China

扫码查看
Cohort evidence linking long-term survival of older adults with exposure to fine particulate matter(PM2.5)constituents remains scarce in China.By constructing a dynamic cohort based on the Chinese Longitudinal Healthy Longevity Study,we aimed to assess the individual and joint associations of major PM2.5 constituents with all-cause death in Chinese oldest-old(≥ 80 years)adults.Time-dependent Cox propor-tional hazards models were adopted to estimate death risks of long-term exposure to PM2.5 constituents.Among 14,884 participants,totaling 56,342 person-years of follow-up,12,346 deaths were identified.The highest mortality risk associated with an interquartile range(IQR)increase in exposure was 1.081(95%confidence interval[CI]:1.055-1.108)for sulfate(IQR=4.1 μg m-3),followed by 1.078(95%CI:1.056-1.101)for black carbon(IQR=1.6 μg m-3),1.056(95%CI:1.028-1.084)for ammonium(IQR=3.2 μg m-3),1.050(95%CI:1.021-1.080)for nitrate(IQR=5.8 μg m-3),and 1.049(95%CI:1.024-1.074)for organic matter(IQR=10.3 μg m-3).In joint exposure,each IQR-equivalent rise of all five PM2.5 constituents was associated with an 8.2%(95%CI:4.0%-12.6%)increase in mortality risk.The weight analysis indicated the predominant role of sulfate and black carbon in driving PM2.5-related mortality.Octogenarians(aged 80-89 years)and rural dwellers were at significantly greater risk of mortality from individual and joint exposures to PM2.5 constituents.This study suggests that later-life exposure to PM2.5 constituents,particularly sulfate and black carbon,may curtail long-term survival of the oldest-old in China.

particulate air pollutionPM2.5 constituentsmortalityoldest-old Chinesecohort studyjoint exposure

Yaqi Wang、Yang Yuan、Shaocai Mo、Fang Wang、Jing Wei、Yao Yao、Yi Zeng、Yunquan Zhang

展开 >

Institute of Social Development and Health Management,Hubei Province Key Laboratory of Occupational Hazard Identification and Control,School of Public Health,Wuhan University of Science and Technology,Wuhan 430065,China

Shenzhen Bao'an District Songgang People's Hospital,Shenzhen 518100,China

School of Public Health,Xuzhou Medical University,Xuzhou 221004,China

Department of Atmospheric and Oceanic Science,Earth System Science Interdisciplinary Center,University of Maryland,College Park,Maryland 20742,USA

China Center for Health Development Studies,Peking University,Beijing 100871,China

Center for Healthy Aging and Development Studies,National School of Development,Peking University,Beijing 100871,China

展开 >

2024

中国科学:生命科学(英文版)
中国科学院

中国科学:生命科学(英文版)

CSTPCD
影响因子:0.806
ISSN:1674-7305
年,卷(期):2024.67(12)