Abstract
Bum wounds are destructive skin traumas typically of irregular shape and large area.Prone to infection,they require frequent dressing replacement,and painless removal of dressings from bum wounds remains a major challenge.This study focuses on the dynamic characteristics and treatment difficulty of burn wounds.Hydrogel dressings based on glycol chitosan and propio-naldehyde-or benzaldehyde-terminated 4-arm poly(ethylene glycol)were designed on the basis of Schiff base cross-linking networks.The hydrogels exhibited shape-adaptability,self-healing and fast-degradation properties,which makes these hydrogels suitable for burn wounds.Salvianolic acid B(SaB)-loaded hydrogel exhibited good antioxidant properties in vitro.In a rat model of deep second-degree bum wounds,the SaB-loaded hydrogel could quickly reduce wound temperature,regulate wound oxidant microenvironment,promote angiogenesis,and accelerate wound healing.Thus,the drug-loaded hydrogel shows significant potential as a first-aid dressing for treatment of bum wounds.
基金项目
国家自然科学基金(52173147)
国家自然科学基金(22105198)
国家自然科学基金(51973218)
国家自然科学基金(51833010)
Scientific and Technological Development Projects of Jilin Province(20210204136YY)
维普
万方数据