首页|Synergistic injection of the thermosensitive hydrogel and Bi-based alloy bone cement for orthopaedic repair

Synergistic injection of the thermosensitive hydrogel and Bi-based alloy bone cement for orthopaedic repair

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Low-melting-point alloys have the advantages of good biocompatibility,plasticity,and near-bone mechanical strength,making them suitable as bone defect-filling materials for direct injection into defective bone sites.However,using low-melting-point alloys for orthopedic implants poses the challenge of causing thermal damage to the surrounding bone tissue during injection.In this study,a thermosensitive hydrogel is prepared and synergistically injected into the bone defect site with BiInSn.BiInSn solidifies and releases heat during injection,while the thermosensitive hydrogel absorbs heat and transforms into a gel state,encapsulating BiInSn.Therefore,the surrounding bone tissue is effectively protected from thermal damage.When BiInSn and the thermosensitive hydrogel were injected synergistically,in vitro thermal experiments revealed that the maximum temperature of the surrounding bone tissue reached 42℃.This temperature is below the 47℃ threshold,which causes permanent damage to bone tissues.In vivo experiments demonstrated that rats in the BiInSn-thermosensitive hydrogel group exhibited better recovery at the bone defect sites.These results suggest that the synergistic injection of Bi-based alloy and thermosensitive hydrogel is beneficial in reducing thermal damage to bone tissue,guiding bone tissue growth,and effectively facilitating the repair of bone defects.

bone defectsthermosensitive hydrogelthermal damage to tissuebismuth-based alloybone cement

LIU SiCong、LI Lei、JIANG ChanYuan、WANG QianYu、DENG ZhongShan

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Key Laboratory of Cryogenic Science and Technology,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China

School of Future Technology,University of Chinese Academy of Sciences,Beijing 100049,China

Department of Cleft Lip and Palate,Plastic Surgery Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100144,China

CAMS Innovation Fund for Medical sciencesKey Laboratory of Congenital Craniofacial Malformation of the Chinese Academy of Medical SciencesFund of CAMS Plastic Surgery HospitalFund of CAMS Plastic Surgery HospitalNational Natural Science Foundation of ChinaFoundation of Director of Technical Institute of Physics and Chemistry Chinese Academy of Sciences

2021I-2 M-1-0522018PT31051Grant Nos.YS202036YS20200331801046

2024

10.1007/s11431-023-2609-6

中国科学:技术科学(英文版)
中国科学院

中国科学:技术科学(英文版)

CSTPCDEI
影响因子：1.056
ISSN：1674-7321
年,卷(期)：2024.(7)
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