A reduced graphene oxide-coated conductive surgical silk suture targeting microresistance sensing changes for wound healing

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外文摘要：Conventional sutures used in surgical procedures often lack the capability to effectively monitor physical and chemical activities or the microbial environment of surgical wounds due to their inadequate mechanical properties,insufficient electrical accuracy and unstability.Here,we present a straightforward layer-by-layer coating technique that utilizes 3-glycidoxypropyltrimethox-ysilane(CA),graphene oxide(GO),and ascorbic acid(AA)to develop conductive silk-based surgical sutures(CA-rGSFS).The CA-rGSFS feature a continuous reduced graphene oxide(rGO)film on their surface,forming robust hydrogen bonds with silk fibroin.The reduction process of rGO is confirmed through Raman analysis,demonstrating an enhanced D peak to G peak ratio.Notably,the CA-rGSFS exhibit exceptional mechanical properties and efficient electron transmission,with a knot-pull tensile strength of 2089.72±1.20 cN and an electrical conductivity of 130.30±11.34 S/m,respectively,meeting the requirements specified by the United States Pharmacopeia(USP)for 2-0 sutures.These novel CA-rGSFS demonstrate the ability to accurately track resistance changes in various fluid environments with rapid response,including saline,intestinal,and gastric fluids.The suture also retains remarkable stretchablility and stability even after enduring 3000 tensile cycles,highlighting their potential for precise surgical site monitoring during the wound healing process.

外文关键词：

layer-by-layer coatingreduced graphene oxidesilk sutureelectrical conductivitymicroresistance sensingwound monitoring

作者：

DING YuQi、WANG XuChen、LIU JingGe、SHEN HongQiang、WANG Zhong、XIE MaoBin、CHEN Ying、BARCENAS Adileidys Ruiz、ZHAO ZeYu、LI Gang

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作者单位：

National Engineering Laboratory for Modern Silk,College of Textile and Clothing Engineering,Soochow University,Suzhou 215123,China

The Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People's Hospital

School of Biomedical Engineering,Guangzhou Medical University,Guangzhou 511436,China

Department of Biomedical Engineering,Tufts University,4 Colby St,Medford MA 02155,USA

National Sericulture Project Research Center in Plant Proteins and Bionatural Products,Havana 11300,Cuba

Department of Applied Physics,The Hong Kong Polytechnic University,Hong Kong 999077,China

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出版年：

2024

DOI：

10.1007/s11431-024-2710-5

中国科学:技术科学(英文版)

中国科学院

中国科学:技术科学(英文版)

CSTPCDEI

影响因子：1.056

ISSN：1674-7321

年,卷(期)：2024.67(11)