高分子囊泡领域面临的挑战和未来研究方向
Challenges and future directions for next-generation biomedical polymersomes
石隽秋 1孙青梅 2王文立 2李畅 2尹海洋 2李浩澜 2滕润鑫 2范震 1朱云卿 2杜建忠1
作者信息
- 1. Department of Gynaecology and Obstetrics,Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation,Clinical Research Center for Anesthesiology and Perioperative Medicine,Translational Research Institute of Brain and Brain-Like Intelligence,Shanghai Fourth People's Hospital,School of Medicine,Tongji University,Shanghai 200434,China;Department of Polymeric Materials,School of Materials Science and Engineering,Tongji University,Shanghai 201804,China
- 2. Department of Polymeric Materials,School of Materials Science and Engineering,Tongji University,Shanghai 201804,China
- 折叠
摘要
作为细胞中的主要运输系统,天然囊泡在物质的定点输运过程中具有至关重要的作用.高分子囊泡是与之结构相似的一种人工囊泡,具有优异的膜稳定性和胶体稳定性、高药物负载率、低膜穿透性、优异的可修饰性和长循环时间等优势,在生物医用领域具有广泛的应用前景.然而,目前该领域尚面临一系列重要挑战,如合成和制备方法较为复杂、生物相容性较难预测、功能和递送途径有限等,限制了其临床转化之路.本文从囊泡的构建模块合成、自组装技术和潜在的生物医学应用等角度,提出了设计和制备下一代高分子囊泡需要解决的五个关键科学问题,指出了未来面临的重要挑战和发展方向,例如简化设计和合成过程,优化和规范自组装过程,拓展潜在的应用前景.
Abstract
As a major transport system in cells,naturally occurring vesicles play an important role to ensure that the right cargo is shipped to the right destination at the right time.Similarly,artificial vesicles,such as polymersomes with simi-lar structures and functions,have been developed for various biological applications due to the advantages of polymersomes such as excellent membrane and colloidal stability,high loading efficiency of hydrophobic drugs,low membrane per-meability,high functional modifiability,and long circulation time.However,relatively complicated synthesis and prepara-tion methods,unpredictable biocompatibility and limited functions and delivery routes,have largely hindered the clinic translation of polymersomes.In this review,we propose five key scientific questions for next-generation polymersomes,in the aspects of synthesis of building blocks,self-assembly techniques,and potential biomedical applications,to empha-size on the future challenges and directions,such as simpli-fying the design and synthetic process,streamlining and standardizing the self-assembly procedure,and broadening the horizon of potential applications.
关键词
polymersomes/self-assembly/biomaterialsKey words
polymersomes/self-assembly/biomaterials引用本文复制引用
基金项目
National Key R&D Program of China(2022YFC2402900)
National Natural Science Foundation of China(21925505)
National Natural Science Foundation of China(22335005)
National Natural Science Foundation of China(52003195)
National Natural Science Foundation of China(52222306)
National Natural Science Foundation of China(22075212)
National Natural Science Foundation of China(22175131)
Innovation Program of Shanghai Municipal Education Commission(2023ZKZD28)
Shanghai International Scientific Collaboration Fund(21520710100)
出版年
2024
NETL
NSTL
万方数据