高吸附电化学纤维传感器用于实时、准确检测颅内一氧化氮
A highly adsorptive electrochemical fiber sensor for real-time and accurate detection of intracranial nitric oxide
高睿 1王列 1李丹 2宋杰 1栗乾明 1卢江 1李录河 1李亦冉 1叶婷婷 1王嘉诚 1焦一丁 1李方琰 1何儿 1任俊烨 1张晔1
作者信息
- 1. National Laboratory of Solid State Microstructures,Jiangsu Key Laboratory of Artificial Functional Materials,Chemistry and Biomedicine Innovation Center,Collaborative Innovation Center of Advanced Microstructures,College of Engineering and Applied Sciences,Nanjing University,Nanjing 210023,China
- 2. Department of Immunology,School of Medicine and Holistic Integrative Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China
- 折叠
摘要
电化学一氧化氮传感器能够实时监测颅内一氧化氮浓度,对于了解大脑中一氧化氮的功能至关重要.然而,在大脑中使用的传统刚性传感电极面临着灵敏度低和植入后神经炎症引起一氧化氮浓度异常的问题.在这里,我们报道了一种结合物理和化学吸附能力、具有高灵敏度和准确性的电化学一氧化氮传感器.其对一氧化氮的物理和化学吸附能力分别来自于电极的高比表面积和丰富的羧基官能团.此外,柔软的电极可以与脑组织的力学性能相匹配,实现了一个高度适应的电极/组织界面.由此设计的颅内一氧化氮传感器表现出迄今为止所报道文献中最高的灵敏度,为3245 pA nmol-1 L,检测限为0.1 nmol L-1.电极在植入后未观察到显著的炎症反应以及过量的一氧化氮表达,提高了检测的准确性.该传感器成功捕捉了大脑中的一氧化氮波动,并实现了对多个脑区的同时检测,促进了对大脑中一氧化氮生理病理作用的研究.
Abstract
Electrochemical nitric oxide(NO)sensors are capable of real-time monitoring of intracranial NO con-centration,which is crucial for understanding the functions of NO in the brain.However,traditional rigid electrochemical sensors used in the brain face the dilemma of low sensitivity and abnormal NO concentrations caused by neuroin-flammatory responses.Here,we report a highly sensitive and accurate electrochemical NO sensor that combines both phy-sical and chemical adsorption capabilities for NO.The phy-sical and chemical adsorption capabilities can be attributed to the high specific surface area and abundant carboxyl func-tional groups of the electrode,respectively.Besides,it is soft and matches the mechanical property of brain tissue,enabling an adaptable interface.The resulting NO sensor exhibits the highest reported sensitivity of 3245 pA nmol-1 L,with a low detection limit of 0.1 nmol L-1.No significant inflammatory response or excess NO expression is observed after implanta-tion,improving the detection accuracy.The sensor success-fully captures NO fluctuations in the brain and enables simultaneous NO detection in multiple brain regions,facil-itating research on NO physio-pathological actions in the brain.
关键词
carbon nanotube fiber/NO sensor/real-time/im-plantable sensorKey words
carbon nanotube fiber/NO sensor/real-time/im-plantable sensor引用本文复制引用
基金项目
国家自然科学基金(22175086)
国家自然科学基金(22005137)
国家自然科学基金(22205098)
国家自然科学基金(82201992)
江苏省自然科学基金(BK20200321)
江苏省自然科学基金(BK20210681)
Postdoctoral Research Foundation of Jiangsu Province(2021K007A)
中国博士后科学基金(2021M700067)
National Postdoctoral Program for Innovative Talents(BX20200161)
Program for Innovative Talents and Entrepreneurs in Jiangsu(JSSCTD202138)
中央高校基本科研业务费专项(021314380234)
Natural Science Foundation of Nanjing University of Chinese Medicine(XPT82201992)
出版年
2024
NETL
NSTL
万方数据