高度灵活可控的多孔MOF膜用于高效药物释放
Highly flexible and controllable hierarchical MOF membrane for efficient drug release
李家馨 1鄢亚超 1房庆霖 1陈颖芝 2景启航 3Hiang Kwee Lee 4王鲁宁2
作者信息
- 1. School of Materials Science and Engineering,University of Science and Technology Beijing,Beijing 100083,China
- 2. School of Materials Science and Engineering,University of Science and Technology Beijing,Beijing 100083,China;Shunde Graduate School of University of Science and Technology Beijing,Foshan,Guangdong 528399,China
- 3. Shunde Graduate School of University of Science and Technology Beijing,Foshan,Guangdong 528399,China
- 4. School of Chemistry,Chemical Engineering and Biotechnology,Nanyang Technological University,21 Nanyang Link,Singapore 637371,Singapore
- 折叠
摘要
具有生物力学和生化活性的敷料在伤口护理和皮肤组织再生中起着至关重要的作用.然而,机械失配和药物释放管理所涉及的问题限制了当前敷料的有效使用.在本工作中,我们报道了一种简单的策略,即采用聚偏二氟乙烯(PVDF)作为底物,通过嵌入不同尺寸的沸石咪唑酸盐框架(ZIF-8)种子,以推动具有均匀蜂窝结构的高柔性金属有机框架(MOF)复合膜的受控生长,用于药物负载和释放.以嵌入的种子为控制中心,形成的多孔膜具有约0.7-3μm的宽孔隙.这种可调节的微尺度孔与ZIF-8中的固有纳米孔不仅可以有效地提高抗炎类药物的负载(姜黄素,CCM),而且还能够快速并可控地释放药物,大大提高了抗菌活性,同时促进细胞生长.其中,在40 nm种子上生长的0.7μm多孔膜的表现优于其他蜂窝膜,与2μm多孔膜(相当于裸PVDF基质)相比,细胞增殖能力提高了约2倍,针对金黄色葡萄球菌(S.aureus)和大肠杆菌(E.coli)的抗菌活性分别提高了5倍和2.4倍,是基底抗菌活性的5倍,这是因为这种最佳孔几何结构具有CCM和Zn2+释放特性的平衡效应.这种可控分层孔阵列膜的独特性质有望真正用于伤口愈合,同时也为生物医学设计提供了新的指导.
Abstract
An active wound dressing that is biomechani-cally and biochemically effective is essential for wound care and skin tissue regeneration.Despite its importance,issues persist with mechanical compatibility and drug release con-trol,restricting the optimal use of existing dressings.In this work,we present a simple approach using a poly(vinylidene fluoride)(PVDF)substrate containing zeolitic imidazolate framework(ZIF-8)seeds of different sizes to start the precise development of a highly flexible metal-organic framework membrane with a consistent honeycomb structure,suitable for drug loading and release.With the embedded seeds serving as a control center,the honeycomb membrane formed features pore openings ranging from 0.7 to 3 μm.These adjustable microscale pores,combined with the intrinsic nanopores in ZIF-8,facilitate efficient loading of the anti-inflammatory drug curcumin(CCM)and enable its rapid and controlled release for antibacterial activity and cell growth.Among these,the 0.7-μm honeycomb membrane produced on the 40-nm seed showed a 2-fold increase in cell proliferation compared with the 2-μm honeycomb membrane(equal to the bare PVDF substrate).Furthermore,it displayed 5 and 2.4 times greater antibacterial activity against Staphylococcus aureus and Es-cherichia coli than the substrate.These results are attributable to the balanced influence of CCM and Zn2+release properties from such ideal pore geometries.The controllable and hier-archical pore-arrayed membrane boasts unique characteristics that make it a promising option for wound healing.Ad-ditionally,it offers valuable insights for the design of future biomedicine applications.
关键词
MOF membrane/hierarchical pores/controllable drug release/cytocompatibilityKey words
MOF membrane/hierarchical pores/controllable drug release/cytocompatibility引用本文复制引用
基金项目
National Natural Science Foundation of China(52371248)
National Key R&D Program of China(2021YFB3802200)
Guangdong Basic and Applied Basic Research Foundation(2023A1515010905)
Scientific and Technological Innovation Foundation of Shunde Graduate School,USTB(BK22BE012)
funding supports from Singapore Ministry of Education(AcRF Tier 1 RS 13/20)
funding supports from Singapore Ministry of Education(RG4/21)
A*STAR Singapore(AME YIRG A2084c0158)
Center of Hydrogen Innovation,National University of Singapore(CHI-P2022-05)
Nanyang Technological University Startup Grants()
出版年
2024
NETL
NSTL
万方数据