Nanomaterials boost the biomedical application of synthetic biology
Synthetic biology applying genetic tools to en-gineer living cells and organisms,has burgeoning biomedical applications ranging from innovative biosensor and bioma-terial design to the recent development of clinical therapeutic agents and vaccines.Nanomaterials are equipped with unique physical,chemical,and biological properties,holding great potential for expanding the biomedical application scenarios of synthetic biology,improving the production efficiency of target medical products,and enhancing the functions of modified organisms.Here,a brief review is provided to highlight the recent progress in synthetic biology boosted by nanomaterials that act as delivery vehicles,signal transduc-tors,function enhancers,and their related preparation and properties.First,it emphasizes the recent achievements of gene nanocarriers,including organic,inorganic,and bionic delivery systems.Second,the research in nanomaterial-medi-ated stimuli-responsive gene expression regulation has been reviewed.Third,the pioneering work in programmable hybrid living materials including nanomaterial/bacterium hybrid systems,and nanomaterial/mammalian cell hybrid systems is summarized.Finally,it is concluded with the current chal-lenges and personal perspectives on the direction of future work in this field.
synthetic biologynanomaterialsgene circuit car-rierssignal transductorshybrid systems
雷琪、赵一帆、刘双语、肖雅方、杨芳、郭伟圣、顾宁
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Department of Minimally Invasive Interventional Radiology,School of Biomedical Engineering & The Second Affiliated Hospital,Guangzhou Medical University,Guangzhou 510260,China
State Key Laboratory of Digital Medical Engineering,Jiangsu Key Laboratory for Biomaterials and Devices,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China
Cardiovascular Disease Research Center,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Medical School,Nanjing University,Nanjing 210093,China
synthetic biology nanomaterials gene circuit car-riers signal transductors hybrid systems
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