基于微流控的仿生细胞封装
Biomimetic cell encapsulations by microfluidics
王经琳 1黄丹青 1方壹乐 1任昊桢 1赵远锦2
作者信息
- 1. Division of Hepatobiliary and Transplantation Surgery,Department of General Surgery,Nanjing Drum Tower Hospital(The Affiliated Hospital of Nanjing University Medical School),Nanjing 210008,China
- 2. Division of Hepatobiliary and Transplantation Surgery,Department of General Surgery,Nanjing Drum Tower Hospital(The Affiliated Hospital of Nanjing University Medical School),Nanjing 210008,China;State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China
- 折叠
摘要
将细胞封装在生物材料中用于器官修复或疾病治疗是一个新兴领域.目前,微流控技术被用于精确控制封装细胞的数量、大小和支架结构.微流控技术提供了设计生物仿生形态的能力,增强封装细胞的活性和功能,从而提高疾病治疗的效果.本文报道了微流控技术在仿生细胞封装方面的最新进展.我们首先简要概述了各种天然衍生的促进细胞功能的仿生结构,如受到细胞、植物、动物和自然反应启发的结构;之后讨论了基于微技术的最新细胞封装方法,并详细描述了相关过程;最后提出了仿生细胞封装在疾病治疗和临床应用中面临的挑战和未来方向.
Abstract
Cell encapsulated in biomaterials for organ re-pair or disease treatment is indeed an emerging field.Cur-rently,microfluidics is being utilized to precisely control the quantity,size,and scaffold structure of encapsulated cells.Specifically,microfluidics offers the ability to design biomi-metic morphologies that enhance the activity and function of encapsulated cells,thereby improving the effectiveness of disease treatment.In this review,we report the latest ad-vancements in microfluidic-based biomimetic cell encapsula-tion.To begin with,we provide a brief overview of various naturally derived biomimetic structures that promote cellular functionality,such as those inspired by cells,plants,animals,and natural responses.Moving forward,we discuss recent cell encapsulation methods based on microtechnology and provide detailed descriptions of the relevant processes.Finally,we address the challenges and future directions of biomimetic cell encapsulation in disease treatment and clinical applications.
关键词
cell encapsulation/microfluidic/biomimetic/organ repair/clinical applicationKey words
cell encapsulation/microfluidic/biomimetic/organ repair/clinical application引用本文复制引用
基金项目
National Natural Science Foundation of China(T2225003)
National Natural Science Foundation of China(82100664)
National Key Research and Development Program of China(2022YFA1105300)
Nanjing Medical Science and Technique Development Foundation(ZKX21019)
Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01)
Guangdong Basic and Applied Basic Research Foundation(2021B1515120054)
出版年
2024
NETL
NSTL
万方数据