基于微流控的仿生细胞封装

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中文摘要：将细胞封装在生物材料中用于器官修复或疾病治疗是一个新兴领域.目前,微流控技术被用于精确控制封装细胞的数量、大小和支架结构.微流控技术提供了设计生物仿生形态的能力,增强封装细胞的活性和功能,从而提高疾病治疗的效果.本文报道了微流控技术在仿生细胞封装方面的最新进展.我们首先简要概述了各种天然衍生的促进细胞功能的仿生结构,如受到细胞、植物、动物和自然反应启发的结构;之后讨论了基于微技术的最新细胞封装方法,并详细描述了相关过程;最后提出了仿生细胞封装在疾病治疗和临床应用中面临的挑战和未来方向.

外文标题：Biomimetic cell encapsulations by microfluidics

外文摘要：Cell encapsulated in biomaterials for organ re-pair or disease treatment is indeed an emerging field.Cur-rently,microfluidics is being utilized to precisely control the quantity,size,and scaffold structure of encapsulated cells.Specifically,microfluidics offers the ability to design biomi-metic morphologies that enhance the activity and function of encapsulated cells,thereby improving the effectiveness of disease treatment.In this review,we report the latest ad-vancements in microfluidic-based biomimetic cell encapsula-tion.To begin with,we provide a brief overview of various naturally derived biomimetic structures that promote cellular functionality,such as those inspired by cells,plants,animals,and natural responses.Moving forward,we discuss recent cell encapsulation methods based on microtechnology and provide detailed descriptions of the relevant processes.Finally,we address the challenges and future directions of biomimetic cell encapsulation in disease treatment and clinical applications.

外文关键词：

cell encapsulationmicrofluidicbiomimeticorgan repairclinical application

作者：

王经琳、黄丹青、方壹乐、任昊桢、赵远锦

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作者单位：

Division of Hepatobiliary and Transplantation Surgery,Department of General Surgery,Nanjing Drum Tower Hospital(The Affiliated Hospital of Nanjing University Medical School),Nanjing 210008,China

State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China

关键词：

cell encapsulation microfluidic biomimetic organ repair clinical application

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaNanjing Medical Science and Technique Development FoundationClinical Trials from Nanjing Drum Tower HospitalGuangdong Basic and Applied Basic Research Foundation

项目编号：

T2225003821006642022YFA1105300ZKX210192022-LCYJ-ZD-012021B1515120054

出版年：

2024

DOI：

10.1007/s40843-024-2903-0

中国科学:材料科学(英文)

CSTPCD

ISSN：

年,卷(期)：2024.67(8)