首页|二维超薄氧化钒纳米片用作催化杀菌剂

二维超薄氧化钒纳米片用作催化杀菌剂

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致病菌引起的感染疾病是对全球公共卫生的严重威胁.目前,抗生素等临床药物存在抗菌作用窄谱、易诱发耐药等根本缺点,而具有生物催化活性的无机纳米功能材料已被用作新型抗菌剂.本研究利用超声辅助液相剥离法,以钒粉(bulk V)的氧化层为原料制备了混合价态二维超薄氧化钒纳米片(VOxNSs),其通过正四和正五价钒的相互转换,可高效催化感染区域富集的H2O2生成羟基自由基(hydroxyl radi-cals,.OH),诱导细菌氧化应激和凋亡.此过程在弱碱和弱酸性环境均可发生,因此不受感染区域pH制约.此外,由于钒的固有特性、二维形貌和合理的价态比,VOxNSs具有广谱抗菌、催化活性高和副产物无毒等优点.这种新型纳米片提供了治疗感染伤口的新策略,扩展了纳米催化医学在抗感染方面的应用.
Two-dimensional ultrathin vanadium oxide nanosheets as catalytic bactericide
Infectious diseases caused by pathogenic bac-teria are a serious threat to global public health.Nowadays,antibiotics and other clinical drugs suffer from some funda-mental disadvantages such as narrow-spectrum antibacterial effect and the risk to induce drug resistance,while inorganic functional nanomaterials with biological catalytic activities have been developed as novel antibacterial agents.In this study,we prepared two-dimensional ultrathin vanadium oxide nanosheets(VOx NSs)with mixed valence states from the oxidised layer of vanadium powder(bulk V)by ultrasonically assisted liquid exfoliation.By conveniently switching between Vv and Vv,VOx NSs can efficiently catalyse H2O2 enriched in bacterially infected areas to generate hydroxyl radicals(·OH),which induce bacterial oxidative stress and apoptosis.This process can occur in both weakly alkaline and acidic en-vironments,thus being independent of the pH value in in-fection areas.In addition,contributed by the intrinsic characteristics of vanadium,two-dimensional morphology and reasonable valence state ratios,VOx NSs exhibit the ad-vantages of broad antibacterial spectrum,high catalytic ac-tivity and non-toxic by-products.This novel nanosheet offers a new strategy to heal infected wounds and extends the appli-cation of nanocatalytic medicine towards anti-infection.

ultrathin nanosheetvanadium oxideFenton-like reactionantibacterial

张志民、郭钊、阮泽松、葛敏、曹士博、袁佳仪、徐甄、范列英、宗明、林翰、施剑林

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State Key Laboratory of High Performance Ceramics and Superfine Microstructures,Shanghai Institute of Ceramics Chinese Academy of Sciences

Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease,Chinese Academy of Medical Sciences,Shanghai 200050,China

Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing 100049,China

Department of Orthopedic Surgery,Shanghai Institute of Microsurgery on Extremities,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China

Department of Electrical and Electronic Engineering,The University of Hong Kong,Hong Kong,China

Department of Clinical Laboratory,Shanghai East Hospital,Tongji University School of Medicine,Shanghai 200120,China

Shanghai Tenth People's Hospital,Shanghai Frontiers Science Center of Nanocatalytic Medicine,School of Medicine,Tongji University,Shanghai 200331,China

Center of Materials Science and Optoelectronics Engineering,University of Chinese A

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ultrathin nanosheet vanadium oxide Fenton-like reaction antibacterial

National Key R&D Program of ChinaShanghai Pilot Program for Basic Research-Chinese Academy of ScienceShanghai BranchNational Natural science Foundation of ChinaNational Natural science Foundation of ChinaNational Natural science Foundation of ChinaBasic Research Program of Shanghai Municipal GovernmentYouth Innovation Promotion Association CASYoung Elite Scientists Sponsorship Program by CASTShanghai Science and Technology Committee Rising-Star ProgramAcademic Leaders Training Program of Pudong Health Bureau of ShanghaiAcademic Leaders Training Program of Pudong Health Bureau of Shanghaishanghai Science and Technology Innovation Action PlanShanghai Municipal Health and Planning CommissionShanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai Jiao Tong University Affiliated Sixth People's Hospital

2022YFB3804500JCYJ-SHFY-2022-00352372276520023912233500621JC14060002023262YESS2021014922QA1410200PWRd2022-032022-321Y11900800202150010DWLL2024-0025DWSY2023-0086

2024

10.1007/s40843-024-2932-3

中国科学:材料科学(英文)

中国科学:材料科学(英文)

CSTPCD
ISSN：
年,卷(期)：2024.67(9)