二维超薄氧化钒纳米片用作催化杀菌剂

Two-dimensional ultrathin vanadium oxide nanosheets as catalytic bactericide

张志民 ¹郭钊 ²阮泽松 ²葛敏 ³曹士博 ⁴袁佳仪 ⁴徐甄 ⁴范列英 ⁴宗明 ⁴林翰 ⁵施剑林⁵

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作者信息

1. State Key Laboratory of High Performance Ceramics and Superfine Microstructures,Shanghai Institute of Ceramics Chinese Academy of Sciences;Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease,Chinese Academy of Medical Sciences,Shanghai 200050,China;Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing 100049,China
2. Department of Orthopedic Surgery,Shanghai Institute of Microsurgery on Extremities,Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200233,China
3. Department of Electrical and Electronic Engineering,The University of Hong Kong,Hong Kong,China
4. Department of Clinical Laboratory,Shanghai East Hospital,Tongji University School of Medicine,Shanghai 200120,China
5. State Key Laboratory of High Performance Ceramics and Superfine Microstructures,Shanghai Institute of Ceramics Chinese Academy of Sciences;Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease,Chinese Academy of Medical Sciences,Shanghai 200050,China;Shanghai Tenth People's Hospital,Shanghai Frontiers Science Center of Nanocatalytic Medicine,School of Medicine,Tongji University,Shanghai 200331,China;Center of Materials Science and Optoelectronics Engineering,University of Chinese A
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摘要

致病菌引起的感染疾病是对全球公共卫生的严重威胁.目前,抗生素等临床药物存在抗菌作用窄谱、易诱发耐药等根本缺点,而具有生物催化活性的无机纳米功能材料已被用作新型抗菌剂.本研究利用超声辅助液相剥离法,以钒粉(bulk V)的氧化层为原料制备了混合价态二维超薄氧化钒纳米片(VOxNSs),其通过正四和正五价钒的相互转换,可高效催化感染区域富集的H2O2生成羟基自由基(hydroxyl radi-cals,.OH),诱导细菌氧化应激和凋亡.此过程在弱碱和弱酸性环境均可发生,因此不受感染区域pH制约.此外,由于钒的固有特性、二维形貌和合理的价态比,VOxNSs具有广谱抗菌、催化活性高和副产物无毒等优点.这种新型纳米片提供了治疗感染伤口的新策略,扩展了纳米催化医学在抗感染方面的应用.

Abstract

Infectious diseases caused by pathogenic bac-teria are a serious threat to global public health.Nowadays,antibiotics and other clinical drugs suffer from some funda-mental disadvantages such as narrow-spectrum antibacterial effect and the risk to induce drug resistance,while inorganic functional nanomaterials with biological catalytic activities have been developed as novel antibacterial agents.In this study,we prepared two-dimensional ultrathin vanadium oxide nanosheets(VOx NSs)with mixed valence states from the oxidised layer of vanadium powder(bulk V)by ultrasonically assisted liquid exfoliation.By conveniently switching between Vv and Vv,VOx NSs can efficiently catalyse H2O2 enriched in bacterially infected areas to generate hydroxyl radicals(·OH),which induce bacterial oxidative stress and apoptosis.This process can occur in both weakly alkaline and acidic en-vironments,thus being independent of the pH value in in-fection areas.In addition,contributed by the intrinsic characteristics of vanadium,two-dimensional morphology and reasonable valence state ratios,VOx NSs exhibit the ad-vantages of broad antibacterial spectrum,high catalytic ac-tivity and non-toxic by-products.This novel nanosheet offers a new strategy to heal infected wounds and extends the appli-cation of nanocatalytic medicine towards anti-infection.

关键词

ultrathin nanosheet/vanadium oxide/Fenton-like reaction/antibacterial

Key words

ultrathin nanosheet/vanadium oxide/Fenton-like reaction/antibacterial

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基金项目

National Key R&D Program of China(2022YFB3804500)

Shanghai Pilot Program for Basic Research-Chinese Academy of Science()

Shanghai Branch(JCYJ-SHFY-2022-003)

National Natural science Foundation of China(52372276)

National Natural science Foundation of China(52002391)

National Natural science Foundation of China(22335006)

Basic Research Program of Shanghai Municipal Government(21JC1406000)

Youth Innovation Promotion Association CAS(2023262)

Young Elite Scientists Sponsorship Program by CAST(YESS20210149)

Shanghai Science and Technology Committee Rising-Star Program(22QA1410200)

Academic Leaders Training Program of Pudong Health Bureau of Shanghai(PWRd2022-03)

Academic Leaders Training Program of Pudong Health Bureau of Shanghai(2022-3)

shanghai Science and Technology Innovation Action Plan(21Y11900800)

Shanghai Municipal Health and Planning Commission(202150010)

Shanghai Jiao Tong University Affiliated Sixth People's Hospital(DWLL2024-0025)

Shanghai Jiao Tong University Affiliated Sixth People's Hospital(DWSY2023-0086)

出版年

2024

中国科学:材料科学(英文)

CSTPCD

ISSN：

段落导航