Synergistic photothermal effect and nanoenzyme for efficient antibacterial activity
The continuous emergence of drug-resistant bacteria has become a serious threat to human and animal health.Developing new non-antibiotic therapeutic drugs with high efficiency and low resistance is a promising strategy for combating drug-resistant bacteria.Here,a novel composite structure based on a hollow metal-organic framework(MOF)wrapped Au nanorod and loaded Pt nanoparticles(Au NR@H-ZIF-8@Pt)is designed for combating drug-resistant bacteria.The Au NR@H-ZIF-8@Pt composite structures serve a twofold purpose:(1)showing superior photothermal conversion effi-ciency under near-infrared light irradiation,thus achieving an antibacterial effect based on photothermal effect,and(2)ex-hibiting high-efficiency peroxidase-like activity,and effec-tively killing bacteria by reactive oxygen species(ROS)generated in situ.By combining photothermal and catalytic effects for in vitro antibacterial experiments,Au NR@H-ZIF-8@Pt exhibits efficient,rapid,broad-spectrum antibacterial activity(99.7％for Pseudomonas aeruginosa and 98.3％for Staphylococcus aureus).In addition,in vivo experiments further demonstrate the advantages of the material in pro-moting bacterial infection wound healing.This study not only facilitates the design of novel biological nanomaterials,but also provides new ideas for combating drug-resistant bacteria.
Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education,Key Laboratory for Matter Microstructure and Function of Hunan Province,Department of Physics and Synergetic Innovation Center for Quantum Effects and Applications,Hunan Normal University,Changsha 410081,China
Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation,College of Life Sciences,Hunan Normal University,Changsha 410081,China
College of Materials Science and Engineering,Hunan University,Changsha 410082,China
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