一种具有定向微通道的机械稳定的自泵油水凝胶敷料用于加速糖尿病伤口愈合

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中文摘要：基于非对称浸润性结构的自泵敷料(SPDs)已发展成为一种用于伤口过量渗液引流的新型有效材料,然而,由于亲、疏水层之间的界面力学稳定性较弱,目前的SPDs容易失去其不对称浸润性.为此,我们通过冰模板辅助浸润诱导转移(WET)聚合策略,制备了一种一体化的、具有定向微通道的自泵油水凝胶敷料(SPD-AM),可以加速糖尿病伤口的愈合过程.WET策略使疏水油凝胶层和亲水水凝胶层之间具有强界面力学稳定性,定向排列的微通道大大提高了SPD的导水能力.以糖尿病大鼠模型为例,相比其他敷料,SPD-AM可显著减少细菌定植,降低炎症反应,促进真皮重塑约47.31％,缩短创面愈合时间约1/5,并最终加速糖尿病创面愈合.本研究对开发下一代面向临床应用的具有稳定力学性能的自泵敷料具有重要价值.

外文标题：A mechanically stable self-pumping organohydrogel dressing with aligned microchannels for accelerated diabetic wound healing

外文摘要：Self-pumping dressings(SPDs)have been de-veloped as a new type of effective material for the drainage of excessive wound exudates based on the structure of asym-metric wettability.However,current SPDs are easy to lose their asymmetric wettability due to the weak interfacial me-chanical stability between the hydrophobic and hydrophilic layers.Herein,we report an integrated self-pumping organo-hydrogel dressing with aligned microchannels(SPD-AM),prepared by an ice-templating-assisted wetting-enabled-transfer(WET)polymerization strategy,that can accelerate the healing process of diabetic wounds.The WET poly-merization strategy enables strong interfacial mechanical stability between the hydrophobic organogel and hydrophilic hydrogel layers.The aligned microchannels greatly improve the draining capability of SPDs.Taking a diabetic rat model as an example,the SPD-AM can significantly reduce the bacterial colonization with low inflammatory responses,enhance der-mal remodeling by about 47.31％,and shorten wound closure time by about 1/5 compared with other dressings,ultimately accelerating diabetic wound healing.This study is valuable for developing next-generation SPDs with stable mechanical performance for clinical applications.

外文关键词：

SPDsmechanically stable interfacesWET strategyice-templatingorganohydrogeldiabetic wounds

作者：

肖五一、万茜子、张益锴、兰晋泽、时连鑫、王树涛

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作者单位：

CAS Key Laboratory of Bio-Inspired Materials and Interfacial Science,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China

University of Chinese Academy of Sciences,Beijing 100049,China

Suzhou Institute for Advanced Research,University of Science and Technology of China,Suzhou 215123,China

关键词：

SPDs mechanically stable interfaces WET strategy ice-templating organohydrogel diabetic wounds

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaYouth Innovation Promotion Association,Chinese Academy of Sciences(CAS)CAS-Croucher Funding Scheme for Joint Laboratories,and China Postdoctoral Science Foundation

项目编号：

2203500821972155220021772220524420220272022M713225

出版年：

2024

DOI：

10.1007/s40843-024-2980-1

中国科学:材料科学(英文)

CSTPCD

ISSN：

年,卷(期)：2024.67(9)