三磷酸腺苷刺激响应型碳点纳米反应器用于T1-增强的磁共振成像介导的化学动力学治疗
Adenosine triphosphate-responsive carbon dots nanoreactors for Ti-weighted magnetic resonance imaging-guided tumor chemodynamic therapy
南福春 1薛小矿 2李建 2梁珂 2王健 2于伟泳 3葛介超 2汪鹏飞2
作者信息
- 1. School of Chemistry and Chemical Engineering,Ministry of Education Key Laboratory of Special Functional Aggregated Materials,Shandong Key Laboratory of Advanced Organosilicon Materials and Technologies,Shandong University,Jinan 250100,China;Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion,Science Center for Material Creation and Energy Conversion,Shandong University,Qingdao 266237,China;Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU
- 2. Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China;School of Future Technology,University of Chinese Academy of Sciences,Beijing 100049,China
- 3. School of Chemistry and Chemical Engineering,Ministry of Education Key Laboratory of Special Functional Aggregated Materials,Shandong Key Laboratory of Advanced Organosilicon Materials and Technologies,Shandong University,Jinan 250100,China;Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion,Science Center for Material Creation and Energy Conversion,Shandong University,Qingdao 266237,China
- 折叠
摘要
设计合成具有肿瘤微环境(如酸、H2O2、谷胱甘肽等)刺激响应型纳米反应器来提高化学动力学治疗(CDT)效果引起了研究者们的广泛关注.目前,探索具有三磷酸腺苷(ATP)刺激响应型纳米反应器用于肿瘤CDT具有重要意义.在此,我们首先制备了具有ATP刺激响应型的铁掺杂碳点(FeCDs).随后利用脂质体将FeCDs与葡萄糖氧化酶(GOx)共组装,得到ATP刺激响应型的纳米反应器.在肿瘤组织中,该纳米反应器首先释放FeCDs与GOx.在ATP刺激下,铁离子能够快速从FeCDs上释放下来引发Fenton/Fenton-like反应产生.OH,实现CDT.于此同时释放的铁离子能够提高材料T1-增强的磁共振成像.并且GOx能够在肿瘤中将葡萄糖转化为H2O2,进而增加·OH的产量,提高CDT治疗效果.本研究提供了一种新型ATP刺激响应型且具有自补充H2O2功能的纳米反应器用于肿瘤诊断与治疗.
Abstract
There are various strategies to conduct tumor microenvironment(TME)stimulus-responsive(e.g.,acid,H2O2 or glutathione)nanoreactors for increasing the effi-ciency of chemodynamic therapy(CDT).Among these,the exploitation of adenosine triphosphate(ATP,another over-expressed biomarker in TME)-responsive nanoreactors for tumor CDT is still challenging.Herein,the ATP-responsive iron-doped CDs(FeCDs)were firstly prepared and then co-assembled with glucose oxidase(GOx)to obtain FeCDs/GOx liposomes as ATP-responsive nanoreactors.Under TME con-ditions,the nanoreactors initially released FeCDs and GOx.Subsequently,with the existence of ATP,iron ions were ra-pidly released from the FeCDs to trigger Fenton/Fenton-like reactions for generating-OH.Meanwhile,the T1-weighted magnetic resonance imaging(MRI)was achieved due to the released iron ions.Moreover,the GOx converted endogenous glucose in tumor to gluconic acid and H2O2 to satisfy the re-quirement of-OH generation.In vitro as well as in vivo ex-periments illustrated that the obtained ATP-responsive CD nanoreactors could be used as a versatile nanotheranostics for simultaneously T1-weighted MRI-guided tumor CDT.This work presents a new ATP-responsive nanoreactor with self-supplied H2O2 for multifunctional nanotheranostic applica-tions.
关键词
carbon dots/adenosine triphosphate/self-supplied H2O2/glucose oxidase/chemodynamic therapyKey words
carbon dots/adenosine triphosphate/self-supplied H2O2/glucose oxidase/chemodynamic therapy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据