摘要
耐药菌的产生已成为全球重大公共卫生问题,并促使人们探索抗生素的替代疗法.利用超分子多肽自组装形成抗菌纳米材料,在治疗耐药菌感染中显示出巨大潜力.本综述重点介绍了近年来通过定制超分子抗菌肽以构筑具有不同自组装纳米结构的抗菌材料,从自组装过程中的驱动力,如疏水作用、氢键、静电作用和π-π堆积等,到所形成的具有不同形貌和尺寸的纳米颗粒、纳米管、纳米纤维和水凝胶等纳米结构及其抗菌活性.最后讨论了超分子自组装抗菌肽所面临的挑战,并展望了未来的发展前景.
Abstract
The emergence of antibiotic-resistant bacteria has become a major threat to global public health and has prompted the discovery of antibiotic alternatives.Natural antimicrobial peptides(AMPs)confer a unique non-specific membrane rupture mechanism,showing great potential in killing drug-resistant bacteria.However,natural AMPs have certain weaknesses,including stability and toxicity issues,which seriously hinder their in vivo applications.Synthetic AMPs possess similar characteristics to natural AMPs,in-cluding positive charges,amphiphilicity,and the ability to fold into diverse secondary structures.These properties are es-sential for AMPs penetration into membranes,allowing them to exhibit antimicrobial effects.Moreover,supramolecular self-assembly,facilitated by hydrophobic interaction,hydro-gen bonding,π-π stacking,and electrostatic interaction,can generate nanoparticles,nanotubes,nanofibers,and hydrogels with well-defined nanoarchitectures.Utilizing peptide self-assembly to form various nanoarchitectures is an effective approach for generating antibacterial nanomaterials,offering potential advantages such as enhanced antibacterial proper-ties,improved stability,and reduced cytotoxicity.This review highlights recent advancements in tailoring supramolecular AMPs to create diverse nano-architectures for combating in-fectious diseases.
NETL
NSTL
万方数据