Tannic acid-based metal-phenolic networks as a versatile platform to mediate cell therapy
Surface modification using biomaterials is crucial for constructing bioactive interfaces that can control cell behavior,regulate biological processes,and interact with specific biomolecules.Tannic acid(TA),a naturally derived polyphenol,is of particular interest due to its ability to com-plex ions,facilitating the fabrication of coordination networks through self-assembly of TA and metal ions,known as metal-phenolic networks(MPNs).These MPNs can form stable,yet dynamic structures that can be further engineered or tailored for specific therapeutic needs.Synthetic TA-based MPN complexes have been constructed to modify diverse biointer-faces due to their unique physiochemical properties,including universal adhesion,pH responsiveness,controllable size and stiffness,ease of preparation,and excellent biocompatibility,which are highly advantageous for various biological applica-tions,particularly in cell therapy.This review explores the synthesis,properties,and applications of TA-based MPNs in the context of therapeutic cells,including bacteria,yeast,and mammalian cells.Key aspects such as biocompatibility,bio-degradability,the ability to modulate cellular environments,and clinical translation are discussed,highlighting the po-tential of TA-based MPNs to advance cell therapy.
Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine,Institute of Molecular Medicine,State Key Laboratory of Systems Medicine for Cancer,Shanghai Cancer Institute,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China
College of Chemistry and Materials Science,Shanghai Normal University,Shanghai 200234,China
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