用于感染性伤口治疗的抗菌-传感一体化绿色共析凝胶
Green eutectogel with antibacterial-sensing integration for infected wound treatment
孟令壮 1孙辉 1张鸿博 1张玉玥 1丁春梅 1徐心源 1李建树2
作者信息
- 1. College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,China
- 2. College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,China;State Key Laboratory of Oral Diseases,Med-X Center for Materials,West China Hospital of Stomatology,Sichuan University,Chengdu 610061,China
- 折叠
摘要
水凝胶是一种高度水合的材料,其结构类似于细胞外基质,具有可调节的机械性能,并可作为功能化的通用平台,用于伤口敷料以防止感染和液体流失.然而,其固有的水分蒸发问题在实际应用中影响了其存储稳定性和使用寿命.深共析溶剂(DESs)是一种环保型溶剂,具有低蒸汽压、导电性好、可降解、不燃和价格适中的特点.采用DES作为溶剂的共析凝胶不仅保留了水凝胶系统的机械强度和功能性,还克服了传统水凝胶中水分蒸发的限制,为更个性化和有效的伤口管理策略提供了有前途的方向和材料框架.本研究成功合成了一种新型三元深共析溶剂,由甘油、氯化锌和氯化胆碱组成,并引入聚合反应性双键,制备了一种环保抗菌的绿色共析凝胶.这种凝胶具有高机械强度、广泛的粘附能力、持久的杀菌活性、优异的传感性能和良好的生物相容性等独特特性.本文对其作为伤口敷料的应用进行了探索,研究结果表明,这种共析凝胶具有加速伤口愈合和防止细菌在伤口部位定植的能力.这些发现为下一代智能伤口敷料的开发提供了坚实的理论基础和有前景的材料平台.
Abstract
Hydrogels,a class of highly hydrated materials mimicking the extracellular matrix,offer tunable mechanical properties and serve as versatile platforms for functionaliza-tion,which have been used for wound dressing to prevent infection and fluid loss.However,their inherent moisture evaporation hampers both storage stability and service life in practical applications.Deep eutectic solvents(DESs),as a ca-tegory of eco-friendly solvents,exhibit low vapor pressure,good conductivity,biodegradability,non-flammability,and affordability.Eutectogels using DESs as a solvent not only retain the mechanical strength and functionality of hydrogel systems but also circumvent the limitations imposed by water evaporation in conventional hydrogels,which presents a pro-mising direction and material framework for more persona-lized and efficacious wound management strategies.In this study,we have successfully synthesized a novel ternary deep eutectic solvent composed of glycerol,zinc chloride,and choline chloride,and subsequently incorporated polymeriz-able double bonds to fabricate an eco-friendly,antimicrobial-sensing eutectogel.This gel possesses a unique combination of high mechanical strength,universal adhesion capabilities,persistent bactericidal activity,superior sensing properties,and excellent biocompatibility.Its potential application as a wound dressing was explored,with results demonstrating the ability of eutectogel to accelerate wound healing and prevent bacterial colonization at the wound site.These findings pro-vide a solid theoretical foundation and a promising material platform for the development of next-generation intelligent wound dressings.
关键词
deep eutectic solvent/eutectogel/wound dressing/conductivity/antibacterialKey words
deep eutectic solvent/eutectogel/wound dressing/conductivity/antibacterial引用本文复制引用
出版年
2024
NETL
NSTL
万方数据