首页|Organelle remodeling during the acquisition and loss of pluripotency

Organelle remodeling during the acquisition and loss of pluripotency

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Pluripotent stem cells hold tremendous promise for regenerative medicine.The mechanisms underlying the acquisition and loss of pluripotency have been revealed at multiple levels.Subcellular mechanisms such as metabolic and organelle remodeling are emerging as critical for pluripotent cell fate transitions.Understanding the rules and roles of organelle remodeling will not only provide important insights into pluripotency regulation,but also help improving application in regenerative medicine.In this review,we summarize recent discoveries in organelle remodeling during the acquisition and loss of pluripotency and discuss how membrane lipids orchestrate organelle remodeling and drive nuclear gene expression.

MitochondriaMembrane lipidsOrganelle remodelingPluripotencyStem cells

WU Yi、CHEN KeShi、XIANG Ge、YING ZhongFu、LIU XingGuo

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CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Joint School of Life Sciences, Institute for Stem Cell and Regeneration, Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences, Guangzhou 510530, China

This work was supported by the National Key Research and Development Program of ChinaThis work was supported by the National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of China

2018YFA01071003162203731631163001

2020

中国科学基金(英文版)
国家自然科学基金会

中国科学基金(英文版)

ISSN：1005-0841
年,卷(期)：2020.28(1)
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