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放射损伤的中医药防治及机制

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核爆炸、核恐怖袭击以及核电站泄露事故等产生的电离辐射严重威胁公众安全,自日本核废水排海以来,再次引发全球对放射损伤及其防治方案的关注.放射损伤涉及多器官、多组织、多系统,现有药物作用单一、毒副作用大,无法全面有效应对.在整体观指导下的中医药防治方案具有多成分、多途径、多靶点的特色."早期清热解毒,中期活血化瘀,晚期养血补血"的中医治疗策略可为放射损伤提供全链条的有效应对策略.因此,本文针对外照射导致放射损伤的血虚证、胃肠病、肺病、生殖病的细胞生物学过程,以及介导放射性核素促排的机制,结合其发生发展的中医病机,总结了现代科学对中医药防治放射损伤的解读.同时,以经典抗辐射中药方剂四物汤和刺白胶囊为例,剖析中医药抗辐射的科学内涵,为放射损伤的中医药防治研究提供新视角.
The Critical Role and The Underlying Mechanism of Traditional Chinese Medicine on Radioprotection
Radiation-induced damage and its prevention schemes have attracted worldwide attention since"Japan's nuclear sewage discharge into the sea".Radiation-induced injury involves in multiple organs,tissues and systems,which cannot be fully and effectively counteracted with the existing drugs that have only single effect and great side effects.Based on the guidance of holistic view,the prevention and treatment scheme of Traditional Chinese Medicine(TCM)are characterized with multiple components,targets and pathways.The TCM plan of"clearing heat and detoxifying in the early stage,activating blood circulation to remove blood stasis in the middle stage,nourishing blood and tonifying blood in the late stage"may provide an effective coping chain s for radiation injury.Currently,TCM prescriptions for blood deficiency syndrome,gastrointestinal diseases,lung diseases,reproductive diseases and internal radiation injuries caused by radiation,as well as their underlying mechanisms were discussed.Besides,the scientific connotation and modernization process of radio-protective TCM were also clarified by taking Siwu decoction and Cibai Capsule as examples.

radiation injurytherapeutic strategyprevention with Traditional Chinese MedicineSiwu decoctionCibai capsule

廖泽彬、邵帅、柏志杰、胡昌坤、高月

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军事医学研究院辐射医学研究所,北京 100850

中国疾病预防控制中心辐射防护与核安全医学所,北京 100088

放射损伤 治疗策略 中医药防治 四物汤 刺白胶囊

国家自然科学基金项目国家自然科学基金项目

8219291182103776

2024

中国科学基金
国家自然科学基金委员会

中国科学基金

CSTPCD北大核心
影响因子:0.62
ISSN:1000-8217
年,卷(期):2024.38(3)