Considerations On Mechanistic and Translational Investigations of Traditional Chinese Medicine for Brain Disorders by Advanced Techniques
Brain disorders emerge as the most severe disorders with characteristics such as high morbidity,lethality/disability rates and burden rate.Now chemical drugs are usually chosen for symptom alleviations in patients with brain disorders.However,current medications face challenges such as side effects and tolerance.Traditional Chinese Medicine(TCM)exhibit unique advantages for both treating and preventing brain disorders.Despite the effectiveness of TCM for brain disorders,however,the lack of in-depth mechanism explanations restricts the inheritance,innovation,and internationalization of TCM.Here,with the perspective of modern scientific research,this article provides considerations and discussions on modernization investigations of TCM for brain disorders through several aspects,including elucidating the mechanisms of TCM theories,the compositional basis and acting mechanisms of classic TCM prescriptions,the mechanisms of acupuncture for brain disorders,as well as the further translational development of new therapies derived from TCM for brain disorders.
Traditional Chinese Medicinebrain disordersmechanistic modernizing investigationstranslational investigation
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