Bile Acids Driving Digestive Tract Inflammation and Cancer Transformation and Traditional Chinese Medicine Prevention and Treatment Trategy
Gastrointestinal cancer has been in the forefront of cancer incidence and mortality in the world for many years,especially in China,which is a great threat to people's life and health.Common gastrointestinal cancers,including liver cancer,gastric cancer,colorectal cancer,esophageal cancer,etc.,are typical inflammation-dependent tumors,and their occurrence is accompanied by the infiltration of inflammatory microenvironment and the evolution of inflammatory cancer transformation Therefore,it is a key scientific issue to explore the driving factors of inflammatory cancer transformation and find effective intervention strategies to target the key nodes of inflammatory cancer transformation,thereby controlling the occurrence of gastrointestinal cancer.As one of the important metabolites of the body,bile acids not only play a normal physiological function,but also play an important role in the process of gastrointestinal inflammatory cancer transformation.The regulation of bile acid metabolism is the key to the prevention and treatment of digestive tract inflammation and cancer transformation.At the same time,based on the theory of liver and spleen of Traditional Chinese Medicine(TCM)and the theory of entero-liver axis,the prevention and treatment strategy of inhibiting digestive tract inflammation transformation through bile pathway was discussed.In this paper,the specific mechanism of bile acid-driven gastrointestinal inflammatory cancer transformation and the prevention and treatment strategies of TCM are discussed,analyzed and prospected.
gastrointestinal cancerinflammatory cancer transformationbile acidsliver-spleen theoryenterohepatic circulation
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