Application and Prospects of the Immune Repertoire(TCR/BCR)as a Novel"Holographic"Biomarker in the TCM Preventive Treatment
The theory of"preventive treatment of diseases"in Traditional Chinese Medicine(TCM)constitutes the main content of health management of TCM.The concept of"preventive treatment of diseases"gives scientific connotation to the health management system of TCM.The establishment and improvement of the health management system is in turn inseparable from the in-depth analysis of the"preventive treatment of diseases"in TCM.The in-depth analysis of the idea of"preventive treatment of diseases"requires deep consideration of three key scientific questions:1)how to objectively describe the biological basis of status of"pre-diseases"and clarify the mechanism;2)how to interpret the scientific concept of"preventive treatment of diseases"and the specific pharmacological effect mechanism of TCM compound;3)how to build a new model of precise health management of TCM with"preventive treatment of diseases"as the core.This paper proposes,from the perspective of regulatory science and for the first-time,new tools,methods and standards for the objective characterization of the new"holographic"immune repertoire(TCR/BCR)biomarker as new scientific evidence to address the above three key scientific questions.