Coronary microvascular dysfunction(CMD)is widely present in various cardiovascular diseases and is closely related to left ventricular remodeling and cardiovascular events.The evolution of this disease is centered around blood stasis.The method of promoting blood circulation and removing stasis can improve the coronary flow reserve(CFR)and index of microcirculatory resistance(IMR)of patients,and has a good therapeutic effect on CMD.In terms of mechanism,the various methods of promoting blood circulation and removing blood stasis regulate many key pathological and physiological aspects of CMD.For example,promoting blood circulation for removing blood stasis can effectively inhibit inflammation,oxidative stress,and thrombosis formation.Dissipating phlegm for promoting blood circulation can protect vascular endothelium,benefiting qi for activating blood circulation can improve energy metabolism,tonifying kidney for promoting blood circulation to promote angiogenesis,and establishing coronary collateral circulation.Applying modern science to deeply explore the mechanisms of various methods for promoting blood circulation and removing blood stasis in the treatment of this disease,to provide a new idea for solving the treatment of this disease.
关键词
冠脉微循环障碍/中医药/活血化瘀/血瘀证/作用机制
Key words
coronary microvascular dysfunction/Traditional Chinese Medicine/promoting blood circulation for removing blood stasis/blood stasis syndrome/mechanism of action
维普
万方数据