Research Progress on Promoting Blood Circulation and Removing Blood Stasis in The Treatment of Coronary Microvascular dDysfunction
Coronary microvascular dysfunction(CMD)is widely present in various cardiovascular diseases and is closely related to left ventricular remodeling and cardiovascular events.The evolution of this disease is centered around blood stasis.The method of promoting blood circulation and removing stasis can improve the coronary flow reserve(CFR)and index of microcirculatory resistance(IMR)of patients,and has a good therapeutic effect on CMD.In terms of mechanism,the various methods of promoting blood circulation and removing blood stasis regulate many key pathological and physiological aspects of CMD.For example,promoting blood circulation for removing blood stasis can effectively inhibit inflammation,oxidative stress,and thrombosis formation.Dissipating phlegm for promoting blood circulation can protect vascular endothelium,benefiting qi for activating blood circulation can improve energy metabolism,tonifying kidney for promoting blood circulation to promote angiogenesis,and establishing coronary collateral circulation.Applying modern science to deeply explore the mechanisms of various methods for promoting blood circulation and removing blood stasis in the treatment of this disease,to provide a new idea for solving the treatment of this disease.
coronary microvascular dysfunctionTraditional Chinese Medicinepromoting blood circulation for removing blood stasisblood stasis syndromemechanism of action