Highly transparent and strong nanohesive hydrogel patch for tissue adhesion
This research aimed to design and fabricate a biocompatible dual-layer chitosan hydrogel adhesive patch with exceptional mechanical properties by employing a nanoadhesive strategy to assess its tissue adhesion performance.The design involves physical cross-linking to construct a robust chitosan hydrogel as a backing membrane,followed by in situ photocuring to create the adhesive hydrogel layer,resulting in an integrated chitosan hydrogel adhesive patch.To facilit-ate adhesion between the hydrogel patch and biological tissue,surface-activated silica nanoparticles serve as interfacial connectors,analogous to nanoglue,promoting binding of the hydrogel to the substrate.Characterization of the patch re-veals an adhesive energy of 282 J/m2 to biological tissues in vitro and a burst pressure of 450 mmHg(1 mmHg=0.133 kPa).The patch exhibits outstanding mechanical properties,with a tensile strength of 4.3 MPa,an elongation rate of 65%,and a fracture toughness of 3.82 kJ/m2.Additionally,the nanohesion-based chitosan hydrogel adhesive patch is highly transparent and demonstrates excellent biocompatibility.It holds promise for applications in various biomedical fields,in-cluding tissue repair and drug delivery,thereby providing a robust material foundation for advancements in clinical surgery.
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维普
