首页|温度反馈指导的双光子金属有机框架材料及其高效光热治疗

温度反馈指导的双光子金属有机框架材料及其高效光热治疗

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实现近红外光热治疗过程的实时温度监控,是肿瘤治疗中的一个重要挑战.本研究通过在MOF-199中组装高光热转换效率的金纳米棒和温度响应型探针PyS,制备了一种智能纳米平台(AMPP).其中,探针PyS由于其特征烯桥键旋转或限制,双光子荧光与温度变化呈线性关系.与此同时,MOF-199在酸性微环境中降解产生的铜离子能够将H2O2转化为·OH,通过类芬顿反应导致肿瘤消融,且该过程可被光热进一步促进.综上,AMPP可以同时实现化学动力治疗以及温度反馈指导的近红外光热治疗,为高效肿瘤治疗提供了一种新材料、新方法.
Temperature-feedback two-photon-responsive metal-organic frameworks for efficient photothermal therapy
The realization of real-time thermal feedback for monitoring photothermal therapy(PTT)under near-infrared(NIR)light irradiation is of great interest and challenge for antitumor therapy.Herein,by assembling highly efficient pho-tothermal conversion gold nanorods and a temperature-responsive probe((E)-4-(4-(diethylamino)styryl)-1-methylpyridin-1-ium,PyS)within MOF-199,an intelligent nanoplatform(AMPP)was fabricated for simultaneous chemodynamic ther-apy and NIR light-induced temperature-feedback PTT.The fluorescence intensity and temperature of the PyS probe are linearly related due to the restriction of the rotation of the characteristic monomethine bridge.Moreover,the copper ions resulting from the degradation of MOF-199 in an acidic microenvironment can convert H2O2 into·OH,resulting in tumor ablation through a Fenton-like reaction,and this process can be accelerated by increasing the temperature.This study es-tablishes a feasible platform for fabricating highly sensitive temperature sensors for efficient temperature-feedback PTT.

metal-organic frameworktwo-photontemperature feedbackphoto thermal therapychemodynamic therapy

孙贤顺、芦鑫、段文瑶、李博、田玉鹏、李丹丹、周虹屏

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安徽大学化学化工学院,安徽合肥 230601

安徽大学物质科学与信息技术研究院,杂化材料结构与功能调控教育部重点实验室,安徽合肥 230601

金属有机框架 双光子 温度反馈 光热治疗 化学动力治疗

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNatural Science Foundation of Anhui Province of China

221710012230500151972001523720732108085MB49

2024

10.52396/JUSTC-2024-0005

中国科学技术大学学报
中国科学技术大学

中国科学技术大学学报

CSTPCD北大核心
影响因子：0.421
ISSN：0253-2778
年,卷(期)：2024.54(6)