神经递质对原发性失眠的作用研究进展
Study on the Role of Neurotransmitters in Primary Insomnia
赵佳丽 1汤永红 1夏凤娟2
作者信息
- 1. 南华大学附属南华医院神经内科,衡阳 421010
- 2. 肇庆市第一人民医院神经内科,肇庆 526060
- 折叠
摘要
原发性失眠是失眠中最常见的一种类型,入睡困难、睡眠维持障碍、早醒、睡眠时间不足或质量差是主要特征,同时影响日常功能,并排除身心疾病所致的失眠(如脑血管疾病、帕金森病、精神障碍,等).大量研究证实中枢神经递质紊乱与失眠密切相关,在维持清醒和困倦中起着重要作用.文中主要探讨单胺类神经递质(去甲肾上腺素、多巴胺、5-羟色胺)、氨基酸类神经递质(谷氨酸、γ-氨基丁酸)和肽类神经递质(食欲素)对原发性失眠的作用.
Abstract
Primary insomnia(PI)is the most common type of insomnia,mainly characterized by difficulty falling asleep,sleep maintenance disorders,early waking,insufficient sleep time or poor quality,while affecting daily function,and precludes insomnia caused by physical and mental diseases(such as cerebrovascular diseases,Parkinson's disease,mental disorders,etc.).A large number of studies have confirmed that central neurotransmitter disorders are closely related to insomnia and play an important role in maintaining wakefulness and sleepiness.The effects of monoamine neurotransmitters(norepinephrine,dopamine,5-hydroxytryptamine),amino acid neurotransmitters(glutamate,γ-aminobutyric acid)and peptide neurotransmitters(orexin)on primary insomnia were investigated.
关键词
原发性失眠/失眠/去甲肾上腺素/多巴胺/5-羟色胺/谷氨酸/γ-氨基丁酸/食欲素Key words
primary insomnia/insomnia/norepinephrine/dopamine/5-hydroxytryptamine/glutamate/γ-aminobutyric acid/orexin引用本文复制引用
基金项目
湖南省卫健委重点指导项目(20201918)
出版年
2024
NETL
NSTL
万方数据