胰岛素样生长因子1参与脑卒中后抑郁的相关性研究进展
Advances in Insulin-like Growth Factor 1 in Poststroke Depression
利凤娇 1马英1
作者信息
- 1. 川北医学院附属医院神经内科,南充市 637000
- 折叠
摘要
脑卒中后抑郁(PSD)是缺血性脑卒中常见并发症.PSD的发病机制复杂.胰岛素样生长因子-1(IGF-1)与神经发生、神经可塑性和情绪调节等密切相关,可能参与PSD的病理生理过程,成为预测PSD的潜在生物标志物及治疗靶点.文中将从IGF-1生物学特性、缺血性脑卒中后IGF-1的变化与PSD的关系以及IGF-1参与PSD的可能机制等方面进行综述.
Abstract
Post-stroke depression(PSD)is a common complication of ischemic stroke(IS),and its pathogenesis is complex.Insulin-like growth factor-1(IGF-1),which is closely related to neurogenesis,neuroplasticity and emotional regulation,may be involved in the pathophysiological process of PSD and could potentially serve as a biomarker and therapeutic target for PSD.The biological characteristics of IGF-1,the correlation between changes in IGF-1 after IS and PSD,and the potential mechanisms through which IGF-1 may be involved in PSD were reviewed.
关键词
脑卒中后抑郁/胰岛素样生长因子1/缺血性脑卒中Key words
poststroke depression/insulin-like growth factor/ischemic stroke引用本文复制引用
基金项目
四川省基层卫生事业发展研究中心资助项目(SWFZ22-Z-03)
南充市研发资金资助项目(22SXZRKX004)
出版年
2024
NETL
NSTL
万方数据