摘要
目的 探讨耐药性癫(癎)患者的T细胞亚群、谷胱甘肽S转移酶(GST)和转化生长因子-β1(TGF-β1)水平与认知功能的关系.方法 选取2021年8月至2023年8月收治的耐药性癫(癎)患者80例设为观察组,同时选取药物敏感性癫(癎)患者80例设为对照组.比较两组T细胞亚群和GST、TGF-β1水平以及简易精神状态检查量表(MMSE)评分差异,同时分析观察组不同临床特征患者T细胞亚群和GST、TGF-β1水平差异以及MMSE量表评分与T细胞亚群和GST、TGF-β1水平的相关性.结果 观察组CD3+和CD4+T细胞均显著低于对照组(P＜0.05),而CD8+T细胞、GST和TGF-β1均显著高于对照组(均P＜0.05).观察组MMSE量表评分显著低于对照组(P＜0.05).观察组定向力、语言能力评分均显著低于对照组(均P＜0.05).观察组MMSE量表评分＜24分患者CD3+和CD4+T细胞明显低于MMSE量表评分＞24分患者(均P＜0.05),而CD8+T细胞、GST和TGF-β1均显著高于MMSE量表评分＞24分患者(P＜0.05).CD3+、CD4+T细胞与MMSE量表评分呈正相关(r=0.651和0.535,P＜0.05),而CD8+T细胞、GST和TGF-β1水平与MMSE量表评分呈负相关(r=-0.338、-0.747和-0.766,P＜0.05).结论 耐药性癫(癇)患者CD3+和CD4+T细胞水平降低,而CD8+T细胞、GST、TGF-β1水平升高,与患者认知损害存在相关性,值得临床进一步研究.
Abstract
Aim To explore the T lymphocyte subpopulations and levels of glutathione S transferase(GST),transforming growth factor β1(TGF-β1)in drug-resistant epilepsy patients,and their relationship with cognitive function.Methods Eighty drug-resistant epilepsy patients who were treated in our hospital from August 2021 to August 2023 were selected as an observation group,while 80 drug-sensitive epilepsy patients were selected as a control group.The differences in T lymphocyte subsets and GST,TGF-1 levels,as well as the scores of the Mini-mental State Examination(MMSE)between the two groups were compared,and the differences in T lymphocyte subsets and GST,TGF-1 levels in patients with different clinical characteristics in the observation group were analyzed,and the correlation between MMSE score and T lymphocyte subpopulations and levels of GST,TGF-1.Results The CD3+and CD4+T lymphocytes in the observation group were significantly lower than those in the control group(P＜0.05),while CD8+T lymphocytes,GST,and TGF-1 were significantly higher than those in the control group(P＜0.05).The MMSE score of the observation group was significantly lower than that of the control group(P＜0.05).The scores of directional ability and language ability in the observation group were significantly lower than those in the control group(P＜0.05).The CD3+and CD4+T lymphocytes in patients with MMSE scores＜24 in the observation group were significantly lower than those with MMSE scores＞24(P＜0.05),while CD8+T lymphocytes,GST,and TGF-1 were significantly higher than those with MMSE scores＞24(P＜0.05).CD3+T lymphocytes and CD4+T lymphocytes were positively correlated with MMSE scores(r=0.651 and 0.535,P＜0.05),while CD8+T lymphocytes,GST,and TGF-1 were negatively correlated with MMSE scores(r=-0.338,-0.747,and-0.766,P＜0.05).Conclusion The levels of CD3+and CD4+T lymphocytes in drug-resistant epilepsy patients decrease,while the levels of CD8+T lymphocytes,GST,and TGF-β1 increase,which is correlated with the patient's cognitive function and worthy of further clinical research.
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